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Current Topics in Microbiology and Immunology

  • W. Henle
  • P. H. Hofschneider
  • P. Koldovský
  • H. Koprowski
  • O. Maaløe
  • F. Melchers
  • R. Rott
  • H. G. Schweiger
  • L. Syruček
  • P. K. Vogt

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 91)

Table of contents

  1. Front Matter
    Pages i-iii
  2. Bernard N. Fields
    Pages 1-24
  3. Deborah H. Spector
    Pages 41-80
  4. Tamar Ben-Porat
    Pages 81-107
  5. G. Wick, R. Boyd, K. Hala, L. De Carvalho, R. Kofler, P. U. Müller et al.
    Pages 109-128
  6. H. Kleinkauf, H. von Döhren
    Pages 129-177
  7. Peter H. Krammer
    Pages 179-215
  8. W. S. Hayward, B. G. Neel
    Pages 217-276

About this book

Introduction

Several discoveries are noteworthy for allowing us to probe the recesses of the virus­ infected cell and to search for cryptic viral genomes which might provide clues in our studies of cancer etiology or developmental biology. One of the most notable was the dis­ covery of reverse transcriptase. This marked a momentous occasion in the history of molecular biology. Not only did it provide insight into the mechanism of persistence of retroviruses but it also provided us with an enzyme that could synthesize a DNA copy of any RNA. This DNA copy could then be used as a hybridization reagent to search for both complementary DNA and viral-specific RNA. Thus one could follow the course of any viral infection or probe in tumor cells for hidden viral genomes. Second, a great deal of credit must be given to the geneticists who isolated the various deletion mutants in the 'avian retrovirus system and thus provided us with the frrst means of isolating gene-spe­ cific probes. Finally, the laboratories which have mapped the genome have provided us with the framework in which to ask very specific questions with our gene-specific probes. Recently, numerous excellent reviews concerning various aspects of the retroviruses have appeared. In this review I shall not even attempt to present a comprehensive review of retroviruses.

Keywords

DNA RNA cell immunology infection microbiology molecular biology retroviruses tumor virus

Editors and affiliations

  • W. Henle
    • 1
  • P. H. Hofschneider
    • 2
  • P. Koldovský
    • 3
  • H. Koprowski
    • 1
  • O. Maaløe
    • 4
  • F. Melchers
    • 5
  • R. Rott
    • 6
  • H. G. Schweiger
    • 7
  • L. Syruček
    • 8
  • P. K. Vogt
    • 9
  1. 1.PhiladelphiaUSA
  2. 2.MartinsriedGermany
  3. 3.DüsseldorfGermany
  4. 4.CopenhagenDenmark
  5. 5.BasleSwitzerland
  6. 6.GießenGermany
  7. 7.Ladenburg/HeidelbergGermany
  8. 8.PragueCzech Republic
  9. 9.Los AngelesUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-68058-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 1981
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-68060-1
  • Online ISBN 978-3-642-68058-8
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site
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