Uric Acid

  • William N. Kelley
  • Irwin M. Weiner

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 51)

Table of contents

  1. Front Matter
    Pages I-XXII
  2. Biochemistry and Physiology of Uric Acid: Production

  3. Biochemistry and Physiology of Uric Acid: Renal Disposal

  4. Biochemistry and Physiology of Uric Acid: Extrarenal Disposal

    1. L. B. Sorensen
      Pages 325-336
  5. Pathology of Uric Acid: Acute Gouty Arthritis

  6. Pathology of Uric Acid: Nephrolithiasis and Urate Nephropathy

  7. Pharmacology of Uric Acid

    1. H. S. Diamond
      Pages 459-484
    2. Gertrude B. Elion
      Pages 485-514
    3. J. M. Brogard, A. Stahl, J. Stahl
      Pages 515-524
    4. S. L. Wallace, N. H. Ertel
      Pages 525-555
  8. Back Matter
    Pages 557-642

About this book


Uric acid has attracted the attention of scientists from a broad spectrum of disciplines, and in recent years dramatic progress has occurred within many of these disciplines. This volume is designed to fill void in the field. Major works in the past five years have provided comprehensive reviews of disorders of uric acid metabolism for the clinical (1-3) as well as short reports of recent progress for the interested scholar (4, 5). In Uric Acid the reader will find extensive reviews of relevant topics selected largely by virtue of recent progress in the field and written by those who, to a considerable extent, qre responsible for that progress. Seven chapters are dedicated to a description of uric acid synthesis, its control, diseases resulting from aberrations in the pathway, and effects of intermediates and end products of this pathway on other metabolic processes. The next five chapters describe our current understanding of the mechanisms by which uric acid is elimi­ nated by the organism. Then seven chapters review the factors responsible for the human "disease" produced by uric acid in the joints and kidneys. The final four chapters provide a summary of therapeutic approaches to control gout, the most important disease caused per se by uric acid.


Drogen Xanthin biochemistry chemistry diseases inflammation kidney metabolism ophthalmology pathology pharmacokinetics pharmacology physiology therapy toxicology

Editors and affiliations

  • William N. Kelley
    • 1
  • Irwin M. Weiner
    • 2
  1. 1.Department of Internal Medicine, Medical SchoolUniversity of MichiganAnn ArborUSA
  2. 2.Department of PathologyUpstate Medical CenterSyracuseUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1978
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-66869-2
  • Online ISBN 978-3-642-66867-8
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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