Antineoplastic and Immunosuppressive Agents

Part II

  • Alan C. Sartorelli
  • David G. Johns

Table of contents

  1. Front Matter
    Pages I-XXXII
  2. Alkylating Agents

  3. Hormones

    1. Fred Rosen, Richard J. Milholland
      Pages 85-103
    2. Russell Hilf, James L. Wittliff
      Pages 104-138
    3. Russell Hilf
      Pages 139-157
    4. Bert W. O’Malley, Charles A. Strott
      Pages 158-169
  4. Antimetabolites

    1. Charles Heidelberger
      Pages 193-231
    2. William A. Creasey
      Pages 232-256
    3. D. H. W. Ho, E. J. Freireich
      Pages 257-271
    4. William H. Prusoff, Barry Goz
      Pages 272-347
    5. J. Škoda
      Pages 348-372
    6. A. R. P. Paterson, D. M. Tidd
      Pages 384-403
    7. Gertrude B. Elion, George H. Hitchings
      Pages 404-425
    8. R. E. Parks Jr., K. C. Agarwal
      Pages 458-467
    9. Joseph R. Bertino
      Pages 468-483
    10. L. L. Bennett Jr.
      Pages 484-511
    11. Paul F. Kruse Jr.
      Pages 512-538
    12. Ti Li Loo
      Pages 544-553
  5. Additional Cytotoxic Agents

    1. Arthur P. Grollman
      Pages 554-570
    2. Herbert T. Abelson, Sheldon Penman
      Pages 571-581
    3. Irving H. Goldberg
      Pages 582-592
    4. A. DiMarco
      Pages 593-614
    5. G. F. Gause
      Pages 615-622
    6. B. K. Bhuyan, C. G. Smith
      Pages 623-632
    7. William B. Kremer, John Laszlo
      Pages 633-641
    8. Susan B. Horwitz
      Pages 642-648
    9. Susan B. Horwitz
      Pages 649-656
    10. Sune Frederiksen, Hans Klenow
      Pages 657-668
    11. William A. Creasey
      Pages 686-694
    12. M. K. Patterson Jr.
      Pages 712-722
    13. Donald J. Reed
      Pages 747-765
    14. E. Mihich
      Pages 766-788
    15. Irwin H. Krakoff
      Pages 789-792
    16. Krishna C. Agrawal, Alan C. Sartorelli
      Pages 793-807
    17. David W. Yesair, Charles J. Kensler
      Pages 820-828
    18. Glen R. Gale
      Pages 829-840
    19. David H. Petering, Harold G. Petering
      Pages 841-849
    20. Paul Pietsch
      Pages 850-876

About this book


Over the past two decades a number of attempts have been made, with varying degrees of success, to collect in a single treatise available information on the basic and applied pharmacology and biochemical mechanism of action of antineoplastic and immunosuppressive agents. The logarithmic growth of knowledge in this field has made it progressively more difficult to do justice to all aspects of this topic, and it is possible that the present handbook, more than four years in preparation, may be the last attempt to survey in a single volume the entire field of drugs employed in cancer chemotherapy and immunosuppression. Even in the present instance, it has proved necessary for practical reasons to publish the material in two parts, although the plan of the work constitutes, at least in the editors' view, a single integrated treatment of this research area. A number of factors have contributed to the continuous expansion of research in the areas of cancer chemotherapy and immunosuppression. Active compounds have been emerging at ever-increasing rates from experimental tumor screening systems maintained by a variety of private and governmental laboratories through­ out the world. At the molecular level, knowledge of the modes of action of established agents has continued to expand, and has permitted rational drug design to play a significantly greater role in a process which, in its early years, depended almost completely upon empirical and fortuitous observations.


cancer chemotherapy drug immunosuppression pharmacology research

Editors and affiliations

  • Alan C. Sartorelli
    • 1
  • David G. Johns
    • 2
  1. 1.Department of PharmacologyYale University School of MedicineNew HavenUSA
  2. 2.Laboratory of Chemical Pharmacology, National Cancer InstituteNational Institutes of HealthBethesdaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1975
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-65808-2
  • Online ISBN 978-3-642-65806-8
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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