Steroids and Brain Edema

1. Mechanisms of Action of Steroids on Brain Edema

   1. Steroids and the Blood-Brain Barrier with Special Reference to Astrocytic Cells

      • Keiji Sano, Hiroshi Hatanaka, Shuji Kamano

      Pages 177-182

   2. Adrenal Cortical Response to Neurosurgical Problems, Noting the Effects of Exogenous Steroids

      • William F. Bouzarth, Henry A. Shenkin, Paul Gutterman

      Pages 183-193

   3. Physiological and Biochemical Findings in the Central Nervous System of Adrenalectomized Rats and Mice

      • Alexander Baethmann, Anthonie Van Harreveld

      Pages 195-202

   4. The Effect of Aldosterone and an Aldosterone-Antagonist on the Metabolism of Perifocal Brain Edema in Man

      • Peter Schmiedek, Alexander Baethmann, Eberhard Schneider, Wolfgang Oettinger, Robert Enzenbach, Frank Marguth et al.

      Pages 203-210

2. Effects of Steroids on Brain Edema in Man

   1. The Effects of Steroids on Brain Edema in Man

      • Joseph Ransohoff

      Pages 211-217

   2. The Clinical Effects of a Synthetic Gluco-Corticoid used for Brain Edema in the Practice of Neurosurgery

      • Robert E. Maxwell, Don M. Long, Lyle A. French

      Pages 219-232

   3. Clinical Experiences with Steroids in Neurosurgical Patients

      • Jan W. F. Beks, H. Doorenbos, G. J. M. Walstra

      Pages 233-238

   4. The Effect of Dexamethasone on Water and Electrolyte Content and on rCBF in Perifocal Brain Edema in Man

      • Hans J. Reulen, Alexander Hadjidimos, Kurt Schürmann

      Pages 239-252

   5. Clinical Studies on the Effect of Corticosteroids on the Ventricular Fluid Pressure

      • Gunvor Kullberg

      Pages 253-258

   6. Double Blind Study of the Effects of Dexamethasone on Acute Stroke

      • Bernard M. Patten, Jerry Mendell, Bertel Bruun, William Curtin, Sidney Carter

      Pages 259-266

3. Back Matter

   Pages 267-306

   PDF

The control of brain edema is still one of the major problems in surgical and conservative treatment of various cerebral lesions. Many attempts have been made to develop methods for reducing the high mortality associated with brain edema. Mter many years of using hypertonic solutions it can be stated that this type of therapy has not yielded satisfactory results. During recent years increasing evidence has been accumulated on the efficacy of steroids on brain edema. Steroids were reported to result in rapid relief of signs and symptoms of increased intracranial pressure and neurological dysfunction accompanying cerebral edema. It was the aim of this workshop to evaluate the effect of corticosteroids on brain edema as an advance in therapy. It was hoped that this could be achieved by a multi­ disciplinary approach. Though, the volume contains the contributions of various experts - internists, neurochemists, neurologists, neuropathologists, neurosurgeons, pharmacologists, physiologists - who have added considerable experimental and clin­ ical evidence on the action of steroids on brain edema. New pathophysiological aspects regarding the mechanisms underlying the formation and resolution of brain The effectiveness of corticosteroid therapy in various forms edema are presented. of clinical and experimental brain edema, e. g. accompanying brain tumors, head injury, spinal cord injury, cerebrovascular lesions, etc. as well as dosage and duration of treatment are critically discussed.

• brain
• brain tumor
• central nervous system
• cerebral ischemia
• growth
• head
• head injury
• inflammation
• mortality
• nervous system
• neurosurgery
• physiology
• spinal cord
• surgery
• therapy

• Neurochirurgische Universitätsklinik Mainz, Mainz, W. Germany

  H. J. Reulen, K. Schürmann

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