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Attempts to Understand Metastasis Formation I

Metastasis-Related Molecules

  • Ursula Günthert
  • Walter Birchmeier

Part of the Current Topics in Microbiology 213/I and Immunology book series (CT MICROBIOLOGY, volume 213/1)

Table of contents

  1. Front Matter
    Pages i-xv
  2. W. C. Powell, L. M. Matrisian
    Pages 1-21
  3. P. Mignatti, D. B. Rifkin
    Pages 33-50
  4. R. Sager, S. Sheng, P. Pemberton, M. J. C. Hendrix
    Pages 51-64
  5. J. P. Johnson, M. M. Rummel, U. Rothbächer, C. Sers
    Pages 95-105
  6. R. C. Elble, B. U. Pauli
    Pages 107-122
  7. M. E. Bracke, F. M. Van Roy, M. M. Mareel
    Pages 123-161
  8. B. Boyer, A. M. Vallés, J. P. Thiery
    Pages 179-194
  9. B. A. Imhof, L. Piali, R. H. Gisler, D. Dunon
    Pages 195-203
  10. N. Montuori, M. E. Sobel
    Pages 205-214
  11. L. Sherman, J. Sleeman, P. Dall, A. Hekele, J. Moll, H. Ponta et al.
    Pages 249-269
  12. U. Günthert
    Pages 271-285
  13. Back Matter
    Pages 288-293

About this book

Introduction

In metastasis, tumor cells disseminate from the primary lesion and home to secondary organs where they may remain dormant for a long time. Metastasis formation is still the most feared manifestation for tumor patients and clinicians. Although improvements have been made concerning earlier detection and specific therapy, most of the cancer patients still die of distant metastases. The pu-rpose of these three volumes is to review the recent progress in molecular metas­ tasis research and to attempt to further understand the biol­ ogy of this multifocal process. With respect to present day molecular biology, the pioneers of metastasis research established the basic concepts of metasta­ sis formation in the 1970s and 1980s, namely, clonal selection of metastatic cells, heterogeneity of metastatic subpopulations, organ specificity of metastasis and the importance of angio­ genesis (Fidler, Kripke, Nicolson, Folkman and others). In the 1980s and 1990s, several of the molecules involved were identified and their network interactions elucidated. These three volumes of Current Topics in Microbiology and Immuno­ logy compile the most recent developments on these meta­ stasis-related molecules; their interactions, regulation, and ways to interfere with their action. It became evident that metastasis-related molecules are confined to distinct cellular compartments, such as the extracellular space, the cell membrane, the cytoplasmic signalling network, and the nuclear regulatory system. For the complex metastatic cascade, proteolysis and alterations in adhesive functions are the most obvious and thus one of the most thoroughly investigated processes.

Keywords

activation biology cancer cell cytokine gene gene therapy growth growth factor immunotherapy membrane molecular biology protein proteins regulation

Editors and affiliations

  • Ursula Günthert
    • 1
  • Walter Birchmeier
    • 2
  1. 1.Basel Institute for ImmunologyBaselSwitzerland
  2. 2.Max-βDelbrūck-Centrum für Molekulare MedizinBerlinGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-61107-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 1996
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64697-3
  • Online ISBN 978-3-642-61107-0
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site
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