Pharmacological Aspects of Drug Dependence

Toward an Integrated Neurobehavioral Approach

  • Charles R. Schuster
  • Michael J. Kuhar

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 118)

Table of contents

  1. Front Matter
    Pages I-XXV
  2. Research in the Study of Drug Action and Addiction

    1. Front Matter
      Pages 1-1
    2. R. W. Pickens, G. I. Elmer, M. C. LaBuda, G. R. Uhl
      Pages 3-52
    3. M. J. Kuhar, C. R. Schuster
      Pages 53-80
  3. Molecular, Behavioral, and Human Pharmacology of Dependence and Consequences

    1. Front Matter
      Pages 81-81
    2. D. R. Compton, L. S. Harris, A. H. Lichtman, B. R. Martin
      Pages 83-158
    3. M. W. Fischman, C.-E. Johanson
      Pages 159-195
    4. L. Dykstra
      Pages 197-232
    5. J. E. Henningfield, R. M. Keenan, P. B. S. Clarke
      Pages 271-314
    6. R. A. Glennon
      Pages 343-371
    7. B. Tabakoff, K. Hellevuo, P. L. Hoffman
      Pages 373-458
  4. Advances in the Pharmacotherapy of Addiction

  5. Back Matter
    Pages 645-658

About this book


In spite of a "war on drugs" that spans years, and in spite of increases in law enforcement efforts and to a lesser extent treatment, substance abuse and dependence continue. While the number of people who experiment with drugs has decreased in recent years, those who use drugs repeatedly, per­ haps several times a week, a measure of "hard core" drug abusers, has not changed, and emergency room visits associated with substances abuse continues to rise. Considering both licit and illicit drug abuse, the number of drug abusers in, for example, the United States is very large and, accordingly, the cost to society is great. A recent Institute of Medicine study suggests that the overall cost is about $66 billion per year (1990 costs). Certainly when assessing the total cost of substance abuse, we must include of the costs of disease and behavioral disorders that are intimately associated with substance abuse. For example, sharing of needles among illicit drug abusers has been and is a critical vector in the spread of drug resistant TB, AIDS, and hepatitis. Further, the use of drugs and alcohol leads to unsafe sexual practices with the attendant risk of AIDS and other sexually transmitted diseases. Tragically, infants are born with drugs in their system and with infections and disease transmitted from the mothers who are drug abusers or their sex partners who are drug abusers.


Calcium HIV alcohol biology chemistry drug drug abuse drug development metabolism pathophysiology pharmacodynamics pharmacokinetics pharmacology physiology research

Editors and affiliations

  • Charles R. Schuster
    • 1
  • Michael J. Kuhar
    • 2
  1. 1.University Psychiatric CenterWayne State University School of MedicineDetroitUSA
  2. 2.Director, The National Institute on Drug AbuseAddiction Research CenterBaltimoreUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1996
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64631-7
  • Online ISBN 978-3-642-60963-3
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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