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Immunopathogenesis of HIV Infection

  • Anthony S. Fauci
  • Giuseppe Pantaleo

Table of contents

  1. Front Matter
    Pages I-VIII
  2. Guiseppe Pantaleo, Cecilia Graziosi, Anthony S. Fauci
    Pages 5-14
  3. Linde Meyaard, Frank Miedema
    Pages 33-51
  4. Oren J. Cohen, Giuseppe Pantaleo, Gordon K. Lam, Anthony S. Fauci
    Pages 53-70
  5. William A. Paxton, Richard A. Koup
    Pages 71-88
  6. Michael L. Greenberg, Simon F. Lacey, Chin-Ho Chen, Dani P. Bolognesi, Kent J. Weinhold
    Pages 103-117
  7. Stephen Norley, Reinhard Kurth
    Pages 139-153

About this book

Introduction

During the last 5 years, major advances have been made in our understanding of the pathogenesis of human immunodeficiency virus (HIV) disease and in the development of new potent antiviral agents. With regard to HIV pathogenesis, several recent observations have not only changed our perspectives of HIV disease, but have been critical for the design of therapeutic strategies. These oberservations include: 1. The delineation of the virologic and immunologic events associated with primary HIV infection. 2. The development of highly sensitive molecular techniques including polymerase chain reaction (PCR) assays for the determination of HIV RNA in plasma, together with the identification of lymphoid tissue as the primary anatomic site for HIV replication and spreading. 3. The characterization of the dynamics of HIV infection. 4. The identification of chemokines with suppressor activity on HIV replication and the discovery of co-receptor molecules for HIV entry.

Keywords

HIV T cell cell immunodeficiency infection lymphocytes pathogenesis resistance virus

Editors and affiliations

  • Anthony S. Fauci
    • 1
  • Giuseppe Pantaleo
    • 2
  1. 1.Laboratory of Immunoregulation National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA
  2. 2.Laboratory of AIDS Immunopathogenesis Department of Medicine Division of Infectious DiseasesCentre Hospitalier Universitaire Vadois (CHUV)LausanneSwitzerland

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-60867-4
  • Copyright Information Springer-Verlag Berlin Heidelberg 1997
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64593-8
  • Online ISBN 978-3-642-60867-4
  • Buy this book on publisher's site
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