The Role of Microenvironment in Axonal Regeneration

Influences of Lesion-Induced Changes and Glial Implants on the Regeneration of the Postcommissural Fornix

  • Christine C. Stichel-Gunkel

Part of the Advances in Anatomy Embryology and Cell Biology book series (ADVSANAT, volume 137)

Table of contents

  1. Front Matter
    Pages I-VIII
  2. Christine C. Stichel-Gunkel
    Pages 1-8
  3. Christine C. Stichel-Gunkel
    Pages 9-9
  4. Christine C. Stichel-Gunkel
    Pages 11-18
  5. Christine C. Stichel-Gunkel
    Pages 19-44
  6. Christine C. Stichel-Gunkel
    Pages 45-58
  7. Christine C. Stichel-Gunkel
    Pages 59-59
  8. Back Matter
    Pages 61-81

About this book


Since the pioneering studies of Ramon y Cajal the inability of lesioned adult CNS axons to regenerate has been well established. During the past years advancements in molecular, cellular and biochemical knowledge have provided new insights into the extrinsic mechanims underlying regeneration failure. The rapid progress in this field has already led to the development of new concepts for therapeutic manipulations. This book provides a comprehensive overview of structural and molecular changes induced by an invasive CNS lesion and their involvements in regeneration processes. Moreover, it demonstrates the strong growth-promoting actitivies of implanted glial cells. The data is discussed in relation to current knowledge on the mechanisms of axonal degeneration and regeneration and in terms of their relevance for the development of novel therapeutic strategies.


cell cell culture central nervous system central nervous systems development extrinsic influences glia glia cell implantation influence lesion-induced changes regeneration tissue

Authors and affiliations

  • Christine C. Stichel-Gunkel
    • 1
  1. 1.Molekulare Neurobiologie, Neurologische KlinikUniversität DüsseldorfDüsseldorfGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1997
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-62787-6
  • Online ISBN 978-3-642-60781-3
  • Series Print ISSN 0301-5556
  • Buy this book on publisher's site
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