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Molecular Signaling and Regulation in Glial Cells

A Key to Remyelination and Functional Repair

  • Gunnar Jeserich
  • Hans H. Althaus
  • Christiane Richter-Landsberg
  • Rolf Heumann

Table of contents

  1. Front Matter
    Pages I-XVI
  2. Signaling for Glial Cells

    1. Front Matter
      Pages 1-1
    2. Cytokines, Growth Factors and Their Intracellular Cascades

      1. Nigel Pringle, Wei-Ping Yu, Ellen J. Collarini, Andy Calver, Anita Hall, Sarah Guthrie et al.
        Pages 3-10
      2. Francesca Aloisi, Francesca Ceccherini Silberstein, Giulio Levi
        Pages 11-19
      3. Hans H. Althaus, Tyede Schmidt-Schultz, Sabine Klöppner
        Pages 20-27
      4. Jean E. Merrill, Bruce D. Howard, Nigel T. Maidment
        Pages 57-68
    3. Ion Channels and Neurotransmitter Receptors

      1. Guillermina Almazan, Amani Khorchid, Hsueh-Ning Liu, Eduardo Molina-Holgado
        Pages 91-100
      2. Harald Sontheimer, Elizabeth Fernandez-Marques
        Pages 101-113
      3. H. Rabe, G. Glassmeier, T.-D. Nguyen, G. Jeserich
        Pages 114-126
      4. Peter Shrager, Sanja D. Novakovi
        Pages 127-138
      5. Rolf Dermietzel
        Pages 139-148
  3. Genes and Proteins of Myelin

    1. Front Matter
      Pages 149-149
    2. Structure, Regulations and Function

      1. Robert M. Gould, Warren D. Spivack
        Pages 151-162
      2. M. Yoshida, K. Kitagawa, D. R. Colman
        Pages 163-169
      3. G. Jeserich, J. Strelau, A. Stratmann
        Pages 170-181
      4. Lynn D. Hudson, Jin G. Kim, Claudia Wiese, Da-Lin Yao, Xia Liu, Henry F. de Webster et al.
        Pages 182-190
      5. Shashi Amur-Umaijee, A. T. Campagnoni
        Pages 191-200
      6. Moritz Rossner, Angelika Bartholomä, Markus Schwab, Klaus-Armin Nave
        Pages 201-209
  4. Neural Repair Mechanisms in the CNS

    1. Front Matter
      Pages 211-211
    2. Cellular Responses to Injury

    3. Remyelination of Lesions in Multiple Sclerosis

    4. Cell Transplantation

  5. Back Matter
    Pages 379-390

About these proceedings

Introduction

An excellent survey of the most recent advances in the area of cellular and molecular biology of glial cells and their involvement in remyelination and functional repair in the CNS. A major part of this book deals with signaling paths within and among neural cells. Glial cells (astrocytes, oligodentrocytes, microglial cells) themselves release substantial amounts of cytokines, growth factors and other signaling molecules, which play an important role during injury and regeneration. Another signaling route between neurons and glial cells follows ion channels and neurotransmitter receptors. In addition to animal models, human oligodentrocytes in cell culture and in the human MS brain are characterized with respect to their immunocytochemistry and function.

Keywords

Activation Development Multiple Sklerose Nervensystem Nervous System Regeneration glia glycoprotein growth factors multiple sclerosis myelination neurons phylogeny proteins regulation

Editors and affiliations

  • Gunnar Jeserich
    • 1
  • Hans H. Althaus
    • 2
  • Christiane Richter-Landsberg
    • 3
  • Rolf Heumann
    • 4
  1. 1.FB Biologie/ChemieUniversität OsnabrückOsnabrückGermany
  2. 2.Max-Planck-Institut für Experimentelle MedizinGöttingenGermany
  3. 3.FB BiologieUniversität OldenburgOldenburgGermany
  4. 4.Molekulare NeurobiochemieUniversität BochumBochumGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-60669-4
  • Copyright Information Springer-Verlag Berlin Heidelberg 1997
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64501-3
  • Online ISBN 978-3-642-60669-4
  • Buy this book on publisher's site
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