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Chromosomal Translocations and Oncogenic Transcription Factors

  • Frank J. RauscherIII
  • Peter K. Vogt

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 220)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Back Matter
    Pages 163-166

About this book

Introduction

Regulation of gene expression at the level of transcription is one of the major determinants of proper cellular proliferation and differentiation. The key players in these processes are sequence-specific DNA binding transcription factor proteins which coordinate programs of gene expression in the nucleus. The articles in this volume document the myriad of genetic and biochemical alterations sustained by human proto-oncogenic transcription factors which result in diverse neoplastic processes. This volume gives insights into how normal programs of gene expression can be subverted by the action of single transcription factors resulting in a specific tumor type. The book provides inspiration for exploiting these tumor-specific alterations as diagnostic, prognostic tools, or as selective therapeutic targets.

Keywords

DNA Krebs cancer chromosome gene gene expression genetics molecular genetics oncogenes proliferation protein proteins regulation transcription tumor

Editors and affiliations

  • Frank J. RauscherIII
    • 1
  • Peter K. Vogt
    • 2
  1. 1.The Wistar InstitutePhiladelphiaUSA
  2. 2.Division of Oncovirology, BCC 239 Department of Molecular and Experimental MedicineThe Scripps Research InstituteLa JollaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-60479-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 1997
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64424-5
  • Online ISBN 978-3-642-60479-9
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site
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