Drug Toxicity in Embryonic Development I

Advances in Understanding Mechanisms of Birth Defects: Morphogenesis and Processes at Risk

  • Robert J. Kavlock
  • George P. Daston

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 124 / 1)

Table of contents

  1. Front Matter
    Pages I-XXVIII
  2. Introduction

    1. R. J. Kavlock, G. P. Daston
      Pages 1-7
  3. Recent Advances in Understanding Normal Development at the Biochemical and Molecular Level

    1. Front Matter
      Pages 9-9
    2. R. Markwald, T. Trusk, A. Gittenberger-de Groot, R. Poelmann
      Pages 11-40
    3. K. Muneoka, R. Anderson
      Pages 41-75
    4. A. Neubüser, R. Balling
      Pages 77-112
    5. J. D. Burrill, H. Saueressig, M. Goulding
      Pages 113-127
    6. R. Maas, M. Rauchman
      Pages 129-182
    7. E. F. Zimmerman
      Pages 183-205
  4. Common Biochemical, Metabolic and Physiological Mechanism of Abnormal Development

    1. Front Matter
      Pages 209-209
    2. T. B. Knudsen
      Pages 211-244
    3. P. E. Mirkes
      Pages 245-275
    4. P. J. Linser
      Pages 277-300
    5. G. T. O’Neill, R. J. Akhurst
      Pages 301-324
    6. T. W. Sadler, E. T. Liu, K. A. Augustine
      Pages 325-337
    7. C. Lau
      Pages 341-372
    8. M. P. Goto, A. S. Goldman
      Pages 433-452
    9. P. G. Wells, P. M. Kim, C. J. Nicol, T. Parman, L. M. Winn
      Pages 453-518
    10. S. M. Bell, C. M. Schreiner, W. J. Scott Jr.
      Pages 549-572
    11. E. W. Carney
      Pages 573-594
  5. Back Matter
    Pages 595-610

About this book


Having received the invitation from Springer-Verlag to produce a volume on drug-induced birth defects for the Handbook of Experimental Pharmacology, we asked ourselves what new approach could we offer that would capture the state of the science and bring a new synthesis of the information on this topic to the world's literature. We chose a three-pronged approach, centered around those particular drugs for which we have a relatively well established basis for understanding how they exert their unwanted effects on the human embryo. We then supplemented this information with a series of reviews of critical biological processes involved in the established normal developmental patterns, with emphasis on what happens to the embryo when the processes are perturbed by experimental means. Knowing that the search for mechanisms in teratology has often been inhibited by the lack of understanding of how normal development proceeds, we also included chapters describing the amazing new discoveries related to the molecular control of normal morphogenesis for several organ systems in the hope that the experimental toxicologists and molecular biologists will begin to better appreciate each others questions and progress. Several times during the last two years of developing outlines, issuing invitations, reviewing chapters, and cajoling belated contributors, we have wondered whether we made the correct decision to undertake this effort.


Geburtsschaden Morphogenese abnormal development birth birth defects drug drugs embryo morphogenesis teratology toxicity

Editors and affiliations

  • Robert J. Kavlock
    • 1
  • George P. Daston
    • 2
  1. 1.Reproductive Toxicology Division (MD-71)National Health and Environmental Effects Research Laboratory, US Environmental Protection AgencyResearch Triangle ParkUSA
  2. 2.Miami Valley LaboratoriesThe Procter and Gamble CompanyCincinnatiUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1997
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64408-5
  • Online ISBN 978-3-642-60445-4
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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