Antiepileptic Drugs

Pharmacology and Therapeutics

  • Mervyn J. Eadie
  • Frank J. E. Vajda

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 138)

Table of contents

  1. Front Matter
    Pages I-XXXVIII
  2. J. O. Willoughby
    Pages 63-85
  3. B. Jarrott
    Pages 87-121
  4. R. L. Macdonald
    Pages 123-150
  5. D. Schmidt
    Pages 151-172
  6. H. Kutt, C. L. Harden
    Pages 229-265
  7. R. G. Dickinson, M. J. Eadie, E. J. E. Vajda
    Pages 267-317
  8. S. C. Schachter
    Pages 319-330
  9. M. C. Walker, J. W. A. S. Sander
    Pages 331-358
  10. D. D. Shen, R. H. Levy
    Pages 359-373
  11. E. Ben-Menachem
    Pages 375-394
  12. C. Kilpatrick
    Pages 395-423
  13. F. J. E. Vajda
    Pages 425-446
  14. S. C. Schachter
    Pages 447-463
  15. D. Heaney, S. Shorvon
    Pages 465-484
  16. I. E. Leppik
    Pages 485-498
  17. W. H. Theodore
    Pages 499-513
  18. E. Perucca
    Pages 515-551
  19. P. N. Patsalos
    Pages 553-587
  20. Back Matter
    Pages 615-631

About this book


In 1985, volume 74 of the Springer-Verlag Handbook of Experimental Phar­ macology, under the editorship of H. -H. Frey and D. Janz, appeared. In this volume the then available data on the topic of antiepileptic drugs were col­ lated and analysed. Over the intervening years knowledge in this area has grown progressively. More new antiepileptic drugs than the total number of agents that were in common use 15 years ago have in the interval either come on to the market or are about to do so. As well, further agents are at a fairly advanced stage of development, whilst the already established drugs have by and large held their places in clinical practice. Knowledge of epileptogenesis has advanced considerably. The mechanisms of action of antiepileptic drugs at the molecular level and in various animal models of epileptic seizures and of the epileptic state are much better understood than they were previously. As well, more information is available concerning the natural history of human epilepsy, and this knowledge is important in making optimal use of the various agents that are now available. Therefore, it has seemed appropriate at this stage in the evolution of knowledge to produce a second volume dealing with Antiepileptic Drugs in the Handbook of Experimental Pharmacology series.


catecholamines chemistry clinical trial cortex drug drug development epilepsy kinetics neuropeptides neuropharmacology neurotransmitter pharmacodynamics pharmacokinetics pharmacology physiology

Editors and affiliations

  • Mervyn J. Eadie
    • 1
  • Frank J. E. Vajda
    • 2
  1. 1.Departments of Medicine, Royal Brisbane HospitalUniversity of QueenslandHerstonAustralia
  2. 2.Australian Centre for Clinical NeuropharmacologySt. Vincent’s HospitalFitzroyAustralia

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1999
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64244-9
  • Online ISBN 978-3-642-60072-2
  • Series Print ISSN 0171-2004
  • Buy this book on publisher's site
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