• Peter Perlmann
  • Hans Wigzell

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 133)

Table of contents

  1. Front Matter
    Pages I-XXV
  2. G. Schild, M. Corbel, P. Corran, P. Minor
    Pages 1-19
  3. S. H. E. Kaufmann, J. Reimann
    Pages 21-42
  4. J. B. Ulmer, J. J. Donnelly, M. A. Liu
    Pages 43-55
  5. F. Schödel, P. Minor
    Pages 121-169
  6. A. Vahlne, T. Bergström, B. Svennerholm
    Pages 171-200
  7. R. Rappuoli, M. Pizza
    Pages 201-224
  8. J. Poolman
    Pages 225-248
  9. J. T. Poolman, C. Laferrière, S. B. Svenson
    Pages 249-272
  10. R. Janssen, D. Young, J. Thole
    Pages 273-289
  11. J. Holmgren, A.-M. Svennerholm
    Pages 291-328
  12. E. G. Sandström
    Pages 329-356
  13. A. M. Schultz
    Pages 357-396
  14. S. Kumar, D. C. Kaslow, S. L. Hoffman
    Pages 397-442
  15. V. C. Stevens
    Pages 443-461
  16. K. E. Hellström, I. Hellström
    Pages 463-478
  17. A. J. Slavin, H. L. Weiner
    Pages 479-498
  18. L. Hellman
    Pages 499-526

About this book


The immune system is the only organ system in the body besides the central nervous systems endowed with memory. Both types of memories are specific and long-lasting, sometimes life long. This memory capacity of the immune system provides the basis for the most cost-efficient of all medical interventions, successful vaccinations against many common infectious diseases. Such a success requires the isolation of the infectious agent or toxic substance, methods to grow and/or purify the relevant antigen and change it into something innocuous whilst maintaining its immunogenicity. Whereas the early vaccines could only use the enhanced resistance against infectious disease as a measure of vaccine efficacy, most modern vaccines rely upon standardized laboratory tests accepted to parallel the in vivo protective capacity to confirm the quality and potency of the respective vaccine. We are presently experiencing an explosion in the development of new and/or improved vaccines. This is largely due to a parallel rapid expansion in our knowledge of the immune system and of the detailed molecular structure and function of microorganisms. Using this knowledge it is now possible to compose vaccines of new types where only certain molecules (or parts of molecules) derived from a pathogen are included, excluding other potentially harmful ones. Whereas earlier attenuated live vaccines were created by em­ pirical means such vaccines can now be created by molecularly defined inter­ ventions in the genome of the microorganism.


Allergie Antigen Autoaggressionskrankheit HIV Krebs Sexually Transmitted Diseases Toxin autoimmune disease immunology infections infectious disease morbidity oncology protein virus

Editors and affiliations

  • Peter Perlmann
    • 1
  • Hans Wigzell
    • 2
  1. 1.The Wenner-Gren Institute Department of Immunology The Arrhenius Laboratories F5Stockholm UniversityStockholmSweden
  2. 2.MTC, Karolinska InstituteStockholmSweden

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1999
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64196-1
  • Online ISBN 978-3-642-59955-2
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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