Neurotrophic Factors

  • Franz Hefti

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 134)

Table of contents

  1. Front Matter
    Pages I-XVIII
  2. Y.-A. Barde
    Pages 1-31
  3. C. F. Ibáñez
    Pages 33-51
  4. C. A. Rask, E. Escandon
    Pages 53-79
  5. D. N. Ishii, S.-F. Pu
    Pages 119-146
  6. N. M. J. Rupniak, J. M. A. Laird, S. Boyce, R. G. Hill
    Pages 147-173
  7. K. Unsicker, C. Suter-Crazzolara, K. Krieglstein
    Pages 189-224
  8. C. Swain, S. Harper, S. Pollack, R. Smith, F. Hefti
    Pages 281-309
  9. Back Matter
    Pages 311-325

About this book


The pharmacology of neurotrophic factors is part of the general field called neuroprotection or neurodegeneration, which has emerged during the past two decades. This new broad research area has identified molecular mechanisms that regulate the morphological plasticity of the nervous system and, in con­ sequence, discovered novel pharmacological approaches to manipulate these processes in disease states. The new, structural neuropharmacology as de­ scribed in this volume attempts to regulate the anatomic aspects of the nervous system and is perhaps comparable to hardware manipulation in computer systems. In contrast, classical neuropharmacology identified multiple ways to modify the function of existing synapses or ion channels in the nervous system, comparable to software manipulations in the computer field. The pharmacol­ ogy of neurotrophic factor is at an early stage and has not produced any major drugs yet. However, the first quintessential clinical trials have been carried out in the past two years or are currently in progress. Rapid further advances can be expected. The discovery of nerve growth factor (NGF), the first protein known to promote survival and growth of nerve cells, led to the discovery of a family of related proteins, the neurotrophins and their receptors. This concept was generalized to incorporate many other protein families that are included in the functional definition of neurotrophic factors, i. e. , proteins able to regulate survival and differentiation of neurons.


Alzheimer´s disease anatomy brain brain injury cerebral ischemia clinical trial growth factor mutagenesis nervous system neurons neuropharmacology pathophysiology pharmacology physiology research

Editors and affiliations

  • Franz Hefti
    • 1
  1. 1.Merck Sharp & DohmeNeuroscience Research CentreHarlowUK

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1999
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64182-4
  • Online ISBN 978-3-642-59920-0
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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