Bioreaction Engineering

Modeling and Control

  • Karl Schügerl
  • Karl-Heinz Bellgardt

Table of contents

  1. Front Matter
    Pages I-XL
  2. Introduction

    1. Karl-Heinz Bellgardt
      Pages 1-18
  3. General Principles and Techniques

    1. Front Matter
      Pages 19-19
    2. Karl Schügerl, Karl-Heinz Bellgardt
      Pages 21-43
    3. Karl-Heinz Bellgardt
      Pages 44-105
    4. Maria I. Klapa, Gregory Stephanopoulos
      Pages 106-124
    5. Bernd Hitzmann
      Pages 125-144
    6. D. Dochain, M. Perrier
      Pages 145-166
    7. Reiner Luttmann, Klaus-Uwe Gollmer
      Pages 167-203
  4. Application of General Principles for Reactor Models

    1. Front Matter
      Pages 205-205
    2. Matthias Reuss, Sven Schmalzriedt, Marc Jenne
      Pages 207-246
    3. Andreas Lübbert
      Pages 247-273
  5. Application of General Principles for Process Models Including Control

    1. Front Matter
      Pages 275-275
    2. Karl Heinz Bellgart
      Pages 277-320
    3. Andreas Lübbert
      Pages 321-348
    4. John Villadsen
      Pages 349-373
  6. Metabolite Flux Analysis, Metabolic Design

    1. Front Matter
      Pages 433-433
    2. Klaus Mauch, Sam Vaseghi, Matthias Reuss
      Pages 435-477
    3. A. Albert de Graaf
      Pages 478-505
    4. Neil S. Forbes, Douglas S. Clark, Harvey W. Blanch
      Pages 556-594
  7. Back Matter
    Pages 595-604

About this book


The book is intended to present various examples for reactor and process modeling and control as well as for metabolic flux analysis and metabolic design at an ad­ vanced level. In Part A, General principles and techniques with regard to reactor and process models, process control, and metabolic flux analysis are presented. In addition the accuracy, precision, and reliability of the measured data are discussed which are ex­ tremely important for process modeling and control. A virtual bioreactor system is presented as well, which can be used for the training of students and operators of industrial plants and for the development of advanced automation tools. In Part B, the General principles are applied for particular bioreactor models. It covers the application of the computational fluiddynamic (CFD) technique to stirred tank and bubble column bioreactors. Different solution methods are presented: the Reynolds-averaging of the turbulent Navier-Stokes equations and modeling of the Reynolds stresses with an appropriate turbulence (k-ee) model, and the Euler (two fluid model), as well as the Euler-Langrange approaches.


Bioreaktionstechnik Biotechnica Biotechnologie Fermenter Glucose Glutamat Lysin Modeling Modelling Segregation Transport biochemical engineering biochemische Technik metabolism optimization

Editors and affiliations

  • Karl Schügerl
    • 1
  • Karl-Heinz Bellgardt
    • 1
  1. 1.Institute of Technical ChemistryUniversity of HannoverHannoverGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2000
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64103-9
  • Online ISBN 978-3-642-59735-0
  • Buy this book on publisher's site
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