© 2000

Origin and Evolution of the Vertebrate Immune System

  • Louis Du Pasquier
  • Gary W. Litman

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 248)

Table of contents

  1. Front Matter
    Pages I-IX
  2. Bridge to Invertebrates

    1. Front Matter
      Pages 1-1
    2. J. P. Rast, Z. Pancer, E. H. Davidson
      Pages 3-16
    3. M. Meister, C. Hetru, J. A. Hoffmann
      Pages 17-36
  3. Major Vertebrate Evolutionary Issues

  4. Origin of Lymphocyte Lineages

  5. Origin of Receptors

    1. Front Matter
      Pages 157-157
  6. Evolution of Receptors

    1. Front Matter
      Pages 187-187
    2. E. Bengtén, M. Wilson, N. Miller, L. W. Clem, L. Pilström, G. W. Warr
      Pages 189-219
    3. T. Ota, T. Sitnikova, M. Nei
      Pages 221-245
  7. Elasmobranchs

    1. Front Matter
      Pages 247-247
    2. M. F. Flajnik, L. L. Rumfelt
      Pages 249-270
    3. J. A. Yoder, G. W. Litman
      Pages 271-282
  8. Somatic Diversification

    1. Front Matter
      Pages 283-283

About this book


The comparative approach to immunology can be traced to the era of Pasteur and Metchnikov in which observations regarding foreign recognition in invertebrates was a factor in the develop­ ment of the principal concepts that created the foundation of what now is the broad field of immunology. With each major experimental and conceptual breakthrough, the classical, albeit essential, question has been asked "are the immune systems of phylogenetically primitive vertebrates and invertebrates similar to that of mammals?" Somewhat surprisingly for the jawed verte­ brates, the general answer has been a qualified form of "yes", whereas for agnathans and invertebrate phyla it has been "no" so far. The apparent abruptness in the appearance of the immune system of vertebrates is linked to the introduction of the somatic generation of the diversity of its antigen specific receptors. Therefore the questions regarding the origin and evolution of the specific immune system revolve around this phenomenon. With respect to the origin of the system (aside from the or­ igin of the rearranging machinery itself, the study of which is still in its infancy) one can ask questions about the cellular and mo­ lecular contexts in which the mechanism was introduced.


Antigen Immunsystem T cell development evolution fish genes genetics histocompatibility immunoglobulin invertebrates phylogeny system transcription vertebrates

Editors and affiliations

  • Louis Du Pasquier
    • 1
  • Gary W. Litman
    • 2
  1. 1.Basel Institute for ImmunlogyBaselSwitzerland
  2. 2.All Children’s HospitalUniversity of South FloridaSt. PetersburgUSA

Bibliographic information

  • Book Title Origin and Evolution of the Vertebrate Immune System
  • Editors L. Du Pasquier
    G.W. Litman
  • Series Title Current Topics in Microbiology and Immunology
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2000
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-3-540-66414-7
  • Softcover ISBN 978-3-642-64078-0
  • eBook ISBN 978-3-642-59674-2
  • Series ISSN 0070-217X
  • Edition Number 1
  • Number of Pages IX, 326
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Immunology
    Human Genetics
  • Buy this book on publisher's site
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