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Immunobiology of Bacterial CpG-DNA

  • Hermann Wagner

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 247)

Table of contents

  1. Front Matter
    Pages I-IX
  2. A. M. Krieg, G. Hartmann, A.-K. Yi
    Pages 1-21
  3. K. J. Stacey, D. P. Sester, M. J. Sweet, D. A. Hume
    Pages 41-58
  4. G. B. Lipford, T. Sparwasser
    Pages 119-129
  5. D. M. Klinman, K. J. Ishii, D. Verthelyi
    Pages 131-142
  6. G. J. Weiner
    Pages 157-170
  7. Back Matter
    Pages 241-248

About this book

Introduction

Bacterial CpG-DNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages and dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules and pro-inflammatory cytokines. As such they act as "natural" adjuvants to promote protective Th1 polarized T cell immune responses. This book is the first comprehensive review of the data emerging in this field.

Keywords

DNA T cell asthma bacteria cancer cell cytokine cytokines immune response immune system immunobiology immunotherapy interferon macrophages vaccine

Editors and affiliations

  • Hermann Wagner
    • 1
  1. 1.Institut für Medizinische MikrobiologieImmunologie und Hygiene der Technischen Universität MünchenMünchenGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-59672-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 2000
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64077-3
  • Online ISBN 978-3-642-59672-8
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site
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