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Neuro-Immune Interactions in Neurologic and Psychiatric Disorders

  • Paul Patterson
  • Claude Kordon
  • Yves Christen
Conference proceedings

Part of the Research and Perspectives in Neurosciences book series (NEUROSCIENCE)

Table of contents

  1. Front Matter
    Pages I-XIV
  2. R. E. Mrak, J. G. Sheng, W. S. T. Griffin
    Pages 9-17
  3. L. Mucke, M. Buttini, R. W. Mahley, R. E. Pitas, J. Raber, T. Wyss-Coray
    Pages 19-33
  4. B. Cordell, L. Yang, A. Naidu, K. Bales, S. Paul, G. Murphy
    Pages 35-46
  5. C. E. Finch, T. E. Morgan, Z. Xie, D. Stone, A.-S. Lanzrein, I. Rozovsky
    Pages 47-56
  6. M. Kubera, M. Maes
    Pages 79-87
  7. R. Dantzer, A. Aubert, R. M. Bluthe, J. R. Konsman, S. Laye, P. Parnet et al.
    Pages 169-184
  8. B. Vernet-der Garabedian, Y. Lemaigre-Dubreuil, N. Delhaye-Bouchaud, J. Mariani
    Pages 185-191
  9. P. Brachet, E. Garcion, C. N. Montero-Menei, S. Nataf, L. Sindji, I. Neveu et al.
    Pages 193-201
  10. Back Matter
    Pages 203-204

About these proceedings

Introduction

This book arrives at the moment when the role of inflammatory processes in neurodegenerative disease, mental illness, and injury is starting to become more widely appreciated. As summarized in these chapters from some of the major laboratories in the field, not only can the brain interact actively with the immune system, but it can generate its own inflammatory responses to stress, certain diseases, and other insults. The contribution of cytokines and other inflammatory molecules to Alzheimer's disease is highlighted here, as is the key importance of the brains's own inflammatory cells, the microglia. Such studies in cell culture and in animal models clearly have the potential to influence clinical practice. The two-way communication between the brain and the immune system is emphasized by experiments showing that infection in peripheral tissues can cause dramatic changes in behavior of animals, while behavioral states such as severe depression can induce marked changes in immune function. These molecular and anatomical bases for such interactions are becoming understood, which will ultimately have therapeutic implications.

Keywords

Alzheimer disease Alzheimer's disease Alzheimer´s disease Neurodegenerative conditions brain depression microglial cells nervous system neuroinflammation neurons neuroprotection neuroscience trauma

Editors and affiliations

  • Paul Patterson
    • 1
  • Claude Kordon
    • 2
  • Yves Christen
    • 3
  1. 1.Biology DivisionCalifornia Institute of TechnologyPasadenaUSA
  2. 2.Centre Paul BrocaINSERM U159ParisFrance
  3. 3.Fondation IPSENParis Cedex 16France

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-59643-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 2000
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64065-0
  • Online ISBN 978-3-642-59643-8
  • Series Print ISSN 0945-6082
  • Buy this book on publisher's site
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