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Viral Proteins Counteracting Host Defenses

  • Ulrich H. Koszinowski
  • Hartmut Hengel

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 269)

Table of contents

  1. Front Matter
    Pages I-XI
  2. A. Gutermann, A. Bubeck, M. Wagner, U. Reusch, C. Ménard, U. H. Koszinowski
    Pages 1-22
  3. N. P. Dantuma, A. Sharipo, M. G. Masucci
    Pages 23-36
  4. E. Reits, A. Griekspoor, J. Neefjes
    Pages 75-83
  5. V. M. Braud, P. Tomasec, G. W. G. Wilkinson
    Pages 117-129
  6. H. E. Farrell, N. J. Davis-Poynter, D. M. Andrews, M. A. Degli-Esposti
    Pages 131-151
  7. R. E. Means, J. K. Choi, H. Nakamura, Y. H. Chung, S. Ishido, J. U. Jung
    Pages 187-201
  8. N. Saederup, E. S. Mocarski Jr
    Pages 235-256
  9. T. Derfuss, E. Meinl
    Pages 257-272
  10. H.-G. Burgert, Z. Ruzsics, S. Obermeier, A. Hilgendorf, M. Windheim, A. Elsing
    Pages 273-318
  11. Back Matter
    Pages 319-328

About this book

Introduction

Viruses that establish long-term or even lifelong infections have evolved sophisticated strategies to counteract a powerful host immune response. Bringing large DNA viruses like adenoviruses and herpesviruses into focus, this book documents a variety of such mechanisms, indicating a very active area of research over the last few years. The repertoire of viral mechanisms interfering with immune functions includes proteins that target antigen presentation pathways to prevent immune recognition or molecules mimicking soluble mediators ("virokines") or chemokine receptors. In view of the highly redundant immune effector mechanisms, the viral functions can teach us the relative biological significance of host defense strategies. Selected and optimized during evolution, the viral inhibitors now serve as unique tools which are perfectly designed to elucidate the molecular anatomy of the pathways that guide immune responses.

Keywords

Antigen processing Chemokine antigen antigen presentation antiviral response apoptosis cytomegalovirus gene histocompatibility immune system infection interferon protein proteins virus

Editors and affiliations

  • Ulrich H. Koszinowski
    • 1
  • Hartmut Hengel
    • 2
  1. 1.Max von Pettenkofer InstituteUniversity of MunichMunichGermany
  2. 2.Robert Koch-InstitutFachgebiet 1.2 Virale InfektionenBerlinGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-59421-2
  • Copyright Information Springer-Verlag Berlin Heidelberg 2002
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-63974-6
  • Online ISBN 978-3-642-59421-2
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site
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