© 1999

Estrogens and Antiestrogens I

Physiology and Mechanisms of Action of Estrogens and Antiestrogens

  • Michael Oettel
  • Ekkehard Schillinger

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 135 / 1)

Table of contents

  1. Front Matter
    Pages I-XXVI
  2. History of Estrogen Research

    1. C. Lauritzen
      Pages 1-14
  3. Chemistry of Estrogens and Antiestrogens

    1. Front Matter
      Pages 15-15
    2. G. Neef
      Pages 17-41
    3. J. A. Dodge, C. D. Jones
      Pages 43-53
    4. E. von Angerer
      Pages 55-80
    5. E. von Angerer
      Pages 81-108
  4. Molecular Biology of Estrogenic Action

    1. Front Matter
      Pages 109-109
    2. A. K. Hihi, W. Wahli
      Pages 111-126
    3. A. Weisz
      Pages 127-151
    4. V. D. Ramirez, J. Zheng
      Pages 171-200
    5. L. T. Seery, J. M. W. Gee, O. L. Dewhurst, R. I. Nicholson
      Pages 201-220
  5. Biosynthesis and Metabolism of Endogenous Estrogens

    1. Front Matter
      Pages 221-221
    2. M. J. Reed, A. Purohit
      Pages 223-242
    3. T. H. Lippert, H. Seeger, A. O. Mueck
      Pages 243-271
  6. Physiology and Pathophysiology of Estrogens

    1. Front Matter
      Pages 273-273
    2. C. Hegele-Hartung
      Pages 299-313

About this book


For many years, Springer has been publishing an impressive series of textbooks of pharmacology which have set standards in medical science. Surprisingly, an extensive overview of the current state of the art in research on estrogens and anti estrogens was still lacking. The present two volumes on estrogens and antiestrogens provide a comprehensive review of a field of research in which remarkable progress has been made over the past few years. New insights into the mechanisms of steroid hormone action resulted in a tremendous number of publications from which new principles of preventive and therapeutic appli­ cations of estrogens and antiestrogens emerged. Although various electronic data bases provide easy access to this copious information, there was a clear necessity for a monograph-style textbook which assesses and summarizes current knowledge in this rapidly expanding field of research. It should be noted, however, that, due to this dynamic development, it is barely possible to comprehensively update every aspect of basic and clinical knowledge on estro­ gens and antiestrogens. Thus, the intention of the editors was to provide the reader with an overview of the "classic" and most recently explored areas of research and stimulate future interests in basic and applied endocrinology. Estrogens were among the first steroid hormones described in the scientific literature. Since they were first isolated, since the chemical, synthesic and pharmacological characterization of naturally occurring estrogens and, later on, of orally active derivatives, estrogen research has produced continu­ ously hallmark results in reproductive endocrinology worldwide.


Antiöstrogen Estrogens Immune System Regulation antiestrogens enzymes metabolism molecular mechanisms pathophysiology physiology Östrogen

Editors and affiliations

  • Michael Oettel
    • 1
  • Ekkehard Schillinger
    • 2
  1. 1.Leiter Forschung und Entwicklung Jenapharm GmbH & Co. KGJenaGermany
  2. 2.Leiter Forschung, Fertilitätskontrolle und HormontherapieBerlinGermany

Bibliographic information

  • Book Title Estrogens and Antiestrogens I
  • Book Subtitle Physiology and Mechanisms of Action of Estrogens and Antiestrogens
  • Editors Michael Oettel
    Ekkehard Schillinger
  • Series Title Handbook of Experimental Pharmacology
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1999
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-3-540-65016-4
  • Softcover ISBN 978-3-642-63667-7
  • eBook ISBN 978-3-642-58616-3
  • Series ISSN 0171-2004
  • Series E-ISSN 1865-0325
  • Edition Number 1
  • Number of Pages XXVI, 409
  • Number of Illustrations 81 b/w illustrations, 2 illustrations in colour
  • Topics Pharmacology/Toxicology
    Biochemistry, general
    Cell Biology
    Molecular Medicine
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