© 1999


The Biochemical and Molecular Basis of Vitamin A and Retinoid Action

  • Heinz Nau
  • William S. Blaner
  • This volume provides a state-of-the-art account of recent advances in retinoid research with major emphasis on metabolism, actions and pharmacologic aspects


Part of the Handbook of Experimental Pharmacology book series (HEP, volume 139)

Table of contents

  1. Front Matter
    Pages I-XXVIII
  2. Metabolism, Pharmocokinetics and Action of Retinoids

    1. Front Matter
      Pages 1-1
    2. S. Vogel, M. V. Gamble, W. S. Blaner
      Pages 31-95
    3. E. Vakiani, J. Buck
      Pages 97-115
    4. W. S. Blaner, R. Piantedosi, A. Sykes, S. Vogel
      Pages 117-149
  3. Binding Proteins and Nuclear Receptors

    1. Front Matter
      Pages 151-151
    2. F. Javier Piedrafita, M. Pfahl
      Pages 153-184
    3. R. L. Beard, R. A. S. Chandraratna
      Pages 185-213
    4. I. G. Schulman, D. Crombie, R. P. Bissonnette, R. Cesario, K. Roegner, G. Shao et al.
      Pages 215-235
  4. Differentiation, Proliferation, and Cancer

    1. Front Matter
      Pages 237-237
    2. K. Nason-Burchenal, E. Dmitrovsky
      Pages 301-322
  5. Development and Teratogenesis

About this book


In the future' the decade of the 1990s will likely be viewed as a Golden Age for retinoid research. There have been unprecedented research gains in the understanding of retinoid actions and physiology; since the retinoid nuclear receptors were first identified and the importance of retinoic acid in develop­ mental processes was first broadly recognized in the late 1980s. Between then and now, our knowledge of retinoid action has evolved from one of a near complete lack of understanding of how retinoids act within cells to one of sophisticated understanding of the molecular processes through which retinoids modulate transcription. In this volume, we have tried to provide a comprehensive update of the present understanding of retinoid actions, with an emphasis on re­ cent advances. The initial chapters of the volume, or Section A, focus on the physicochemical properties and metabolism of naturally occurring retinoids: - N OY provides an uncommonly encountered view of retinoid effects from the perspective of the physiochemical properties of retinoids. - V AKIANI and BUCK lend a perspective on the biological occurrence and actions of retro- and anhydro-retinoids. Section B considers both the retinoid nuclear receptors and their mechanisms of action as well as synthetic retinoids that have been used exper­ imentally to provide mechanistic insights into receptor actions and have potential therapeutic use for treating disease: - PIEDRAFITA and PFAHL provide a comprehensive review of retinoid nuclear receptor biochemistry and molecular biology.


Nuclear receptors Regulation Retinoide Retinoids Sperma Teratogenesis Vitamin A metabolism

Editors and affiliations

  • Heinz Nau
    • 1
  • William S. Blaner
    • 2
  1. 1.Department of Food Toxicology Center of Food ScienceSchool of Veterinary MedicineHannoverGermany
  2. 2.Department of Medicine Division of Preventive Medicine & NutritionCollege of Physicians and Surgeons of Columbia UniversityNew YorkUSA

Bibliographic information

  • Book Title Retinoids
  • Book Subtitle The Biochemical and Molecular Basis of Vitamin A and Retinoid Action
  • Editors Heinz Nau
    William S. Blaner
  • Series Title Handbook of Experimental Pharmacology
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1999
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-3-540-65892-4
  • Softcover ISBN 978-3-642-63614-1
  • eBook ISBN 978-3-642-58483-1
  • Series ISSN 0171-2004
  • Series E-ISSN 1865-0325
  • Edition Number 1
  • Number of Pages XXVIII, 619
  • Number of Illustrations 73 b/w illustrations, 6 illustrations in colour
  • Topics Pharmacology/Toxicology
    Biochemistry, general
    Molecular Medicine
    Cancer Research
  • Buy this book on publisher's site
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