Neuronal Nicotinic Receptors

  • Francesco Clementi
  • Diego Fornasari
  • Cecilia Gotti

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 144)

Table of contents

  1. Front Matter
    Pages I-XXXI
  2. Introduction to Neuronal Nicotinic Receptors

  3. Genes, Structure, and Distribution of Neuronal Nicotinic Receptors

  4. Functional Properties

  5. Pharmacological Properties

  6. The Role of Nicotinic Acetylcholine Receptors in Neuronal Functions

  7. Back Matter
    Pages 813-821

About this book


Neuronal nicotinic receptors are key molecules for signal transduction in a number of neuronal pathways. They are widely distributed in the brain and are known to be involved in cognitive tasks, including learning and memory, in smoking addiction and in several brain diseases, such as Alzheimer's and Parkinson's dementias, schizophrenia, and epilepsy. This book provides a comprehensive review of the field, starting with a historical perspective and dealing with the molecular structure of these receptors, their biophysical and pharmacological properties, their distribution in central and peripheral nervous systems, and their major involvement in brain functions. Particular emphasis is paid to drugs (both new and old) that are useful in the diagnosis and treatment of diseases involving neuronal nicotinic receptors. Finally, the relevance of these receptors in smoking addiction is carefully evaluated, together with future trends and the latest results.


Alzheimer Degenerative Diseases Exploration Nervous System Neuroreceptors Neurorezeptor Nicotin Receptors Nicotinic Drugs Parkinson Sucht dementia diagnosis neurobiology neurons regulation

Editors and affiliations

  • Francesco Clementi
    • 1
  • Diego Fornasari
    • 1
  • Cecilia Gotti
    • 1
  1. 1.Università degli Studi di Milano Dipartimento di FarmacologiaChemoterapia e Tossicologia Medica “Emilio Trabucchi”MilanoItaly

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heildelberg 2000
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-63027-9
  • Online ISBN 978-3-642-57079-7
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Pharmacology & Toxicology
Consumer Packaged Goods