Purinergic and Pyrimidinergic Signalling II

Cardiovascular, Respiratory, Immune, Metabolic and Gastrointestinal Tract Function

  • Maria Pia Abbracchio
  • Michael Williams

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 151 / 2)

Table of contents

  1. Front Matter
    Pages I-XXVIII
  2. Cardiovascular and Renal Systems

    1. Front Matter
      Pages 1-1
    2. R.M. Broad, Joel Linden
      Pages 3-32
    3. E.K. Jackson
      Pages 33-71
    4. A. Pelleg, G. Vassort
      Pages 73-99
    5. S.M.O. Hourani
      Pages 121-139
    6. G. Burnstock
      Pages 141-238
    7. I. Biaggioni, I. Feoktistov
      Pages 239-279
    8. C. D. Wegner
      Pages 281-300
  3. Immune System

    1. Front Matter
      Pages 301-301
    2. M.C. Montesinos, B.N. Cronstein
      Pages 303-321
    3. G.R. Dubyak
      Pages 323-354
    4. F.Di Virgilio, V. Vishwanath, D. Ferrari
      Pages 355-374
    5. P. Petit, D. Hillaire-Buys, M.M. Loubatières-Mariani, J. Chapal
      Pages 377-391
  4. Back Matter
    Pages 435-442

About this book


Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.


Diabetes Pathophysiologie Purine Purines Pyrimidine adenosine bone endothelium entities new therapeutic pathophysiology physiology receptor signaling signaling system tissue

Editors and affiliations

  • Maria Pia Abbracchio
    • 1
  • Michael Williams
    • 2
  1. 1.Institute of Pharmacological SciencesUniversity of MilanMilanItaly
  2. 2.Department of Molecular Pharmacology and Biological ChemistryNorthwestern University Medical SchoolChicago

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2001
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-67848-9
  • Online ISBN 978-3-642-56921-0
  • Series Print ISSN 0171-2004
  • Buy this book on publisher's site
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