Mechanisms of Organ Dysfunction in Critical Illness

  • Timothy W. Evans
  • Mitchell P. Fink

Part of the Update in Intensive Care and Emergency Medicine book series (volume 38)

Table of contents

  1. Front Matter
    Pages I-XVI
  2. Mitochondrial Biology

  3. Leukocytes and Cell Signaling Mechanisms in Inflammation

  4. Microcirculatory Dysfunction

    1. Front Matter
      Pages 173-173
    2. B. Vallet, E. Wiel, P.-A. Rodie-Talbère
      Pages 175-190
    3. A. W. Sielenkämper, C. G. Ellis, P. Kvietys
      Pages 191-202
  5. Lung and Kidney

    1. Front Matter
      Pages 203-203
    2. S. J. Finney, S. J. Wort, T. W. Evans
      Pages 205-221
    3. M. R. Losser, V. Faivre, D. Payen
      Pages 239-252
    4. B. de Vries, M. A. R. C. Daemen, W. A. Buurman
      Pages 253-264
  6. Gastrointestinal Tract

    1. Front Matter
      Pages 265-265
    2. A. J. Bauer, J. C. Kalff, N. T. Schwarz
      Pages 267-281
    3. P. Radermacher, M. Matejovic, U. B. Brückner
      Pages 301-312
  7. Brain Injury

    1. Front Matter
      Pages 313-313
    2. S. Ivanova, C. J. Czura, K. J. Tracey
      Pages 315-326
    3. P. Kochanek, R. S. B. Clark
      Pages 327-338
    4. P. D. Hurn, A. Bhardwaj, R. J. Traystman
      Pages 339-347
  8. Organ Dysfunction: Detection and Intervention

    1. Front Matter
      Pages 349-349
    2. T. Whitehead, A. S. Slutsky
      Pages 363-375
    3. J-L. Vincent, F. Lopes Ferreira
      Pages 394-403
  9. Back Matter
    Pages 405-410

About this book


The pathophysiology of sepsis can be regarded as a series of steps, beginning with the invasion of normally sterile tissue by microbes and the elaboration of various pro-inflammatory mediators. The final common pathway is often the development of the multiple organ dysfunction syndrome (MODS). Whereas a great deal has been learned during the past quarter century about the inflammatory processes associated with sepsis (and other related conditions, such as ischemia/reperfusion injury), our understanding is far less developed with respect to the pathophysiological events that lead to organ dysfunction under these conditions. Nevertheless, efforts by both clinical and laboratory scientists are leading to new knowledge in this area. The chapters in this volume provide a state-of-the-art overview of many aspects of the pathophysiology of organ dysfunction in critical illness.


Sepsis Trauma brain injury cerebral ischemia hypoxia mechanical ventilation multiple organ failure shock

Editors and affiliations

  • Timothy W. Evans
    • 1
  • Mitchell P. Fink
    • 2
  1. 1.Intensive Care UnitRoyal Brompton HospitalLondonUK
  2. 2.Division of Critical Care MedicineUniversity of Pittsburgh Medical CenterPittsburghUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2002
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-42692-9
  • Online ISBN 978-3-642-56107-8
  • Series Print ISSN 0933-6788
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology