The Macrophage as Therapeutic Target

  • Siamon Gordon

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 158)

Table of contents

  1. Front Matter
    Pages I-X
  2. General

    1. Front Matter
      Pages 1-1
    2. G. Kraal, N. van Rooijen
      Pages 55-65
    3. S. Y. C. Wong, L. Martinez-Pomares
      Pages 67-87
    4. D. R. Greaves, S. Gordon
      Pages 89-107
  3. Macrophage Targets in Inflammation

    1. Front Matter
      Pages 109-109
    2. F. Di Virgilio, D. Ferrari
      Pages 131-146
    3. W. J. S. de Villiers, D. R. van der Westhuyzen
      Pages 147-172
    4. P. C. Calder, P. Yaqoob
      Pages 173-192
    5. J. M. Aerts, C. Hollak, R. Boot, A. Groener
      Pages 193-208
    6. J. A. Mahoney
      Pages 253-268
    7. Z. Johnson, A. Frauenschuh, A. E. I. Proudfoot
      Pages 269-294
    8. T. Ganz, R. I. Lehrer
      Pages 295-304
    9. P. M. Henson
      Pages 305-334
  4. Modulation of Specialised Macrophage Activities

  5. Back Matter
    Pages 479-496

About this book


During the past decade, the rapid growth of molecular and cellular knowledge of macrophages, as a specialized host defense and homeostatic system, has begun to offer attractive targets for therapeutic intervention. Macrophages play a central role in a wide range of disease processes, from genetically determined lysosomal storage diseases, to acute sepsis, chronic inflammation and repair, tissue injury and cell death. Under- or overactivity of macrophage clearance, immune effector functions and responses to metabolic abnormalities contribute to common disorders such as autoimmunity, atherosclerosis, Alzheimer’s disease and major infections including AIDS and Tuberculosis. Whilst the goals of therapeutic intervention based on improved understanding of macrophage functions and their contribution to pathogenesis may seem self evident, there are considerable difficulties in producing useful new agents.

The present volume covers a range of subjects and provides opportunities for a more focused macrophage-targeted approach. The individual chapters review selected topics briefly, to place cellular processes and molecular targets in perspective. Overall, the volume should provide a broad sample of the state of the art. Useful reviews and references in the literature are cited within individual chapters.


AIDS Antigen Chemokine Sepsis drugs immunology infection infections macrophages receptors

Editors and affiliations

  • Siamon Gordon
    • 1
  1. 1.Sir William Dunn School of PathologyUniversity of OxfordOxfordUK

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2003
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-62919-8
  • Online ISBN 978-3-642-55742-2
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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