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The Ontogenesis of Cortical Circuitry: The Spatial Distribution of Synapses in Somesthetic Cortex of Newborn Dog

  • Mark E. Molliver
  • Hendrik Van der Loos
Conference proceedings

Table of contents

  1. Front Matter
    Pages N1-5
  2. Mark E. Molliver, Hendrik Van der Loos
    Pages 7-13
  3. Mark E. Molliver, Hendrik Van der Loos
    Pages 14-27
  4. Mark E. Molliver, Hendrik Van der Loos
    Pages 27-37
  5. Mark E. Molliver, Hendrik Van der Loos
    Pages 37-49
  6. Mark E. Molliver, Hendrik Van der Loos
    Pages 50-50
  7. Back Matter
    Pages 50-54

About these proceedings

Introduction

The ontogenesis of cortical circuitry is the subject of the investigation reported in this paper!. Strategie elements of cortical circuitry are synaptic contacts: sites of neuronal interaction. If we first determine the location of early formed synap­ ses, we may then seek the pre-and postsynaptic elements, that is, the structures which meet and interact at each synaptic junction. The dynamic aspects of cortical development cannot be studied directly: neuronal growth cannot be observed in an intact brain. The pattern of develop­ ment can be approached only by the analysis of static properties at multiple ages. We have selected the newborn dog as a starting point for these studies. Our observations have been restricted to a small portion of primary somesthetic cor­ tex. This region was selected because, in mature cortex, its input and physiologie properties are relatively weIl known. It is particularly advantageous to study a primary sensory projection area because its morphologie development can be di­ rectly related to its functional development. (A related investigation of the onto­ genesis of electrical activity in somesthetic cortex of the dog will be reported separately). A selective review of the literature is necessary in order to place this work in the context of a few relevant phenomena of cortical development.

Keywords

Cortex Synapses development growth morphology physiology

Authors and affiliations

  • Mark E. Molliver
    • 1
  • Hendrik Van der Loos
    • 1
  1. 1.Department of Anatomy, School of MedicineThe Johns Hopkins UniversityBaltimoreUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-51631-3
  • Copyright Information Springer-Verlag Berlin Heidelberg 1970
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-04797-1
  • Online ISBN 978-3-642-51631-3
  • Series Print ISSN 0301-5556
  • Series Online ISSN 2192-7065
  • Buy this book on publisher's site
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