Advertisement

Superantigens

  • Bernhard Fleischer
  • Hans Olov Sjögren

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 174)

Table of contents

  1. Front Matter
    Pages I-IX
  2. T. Herrmann, H. R. MacDonald
    Pages 21-38
  3. T. Chatila, P. Scholl, F. Spertini, N. Ramesh, N. Trede, R. Fuleihan et al.
    Pages 63-79
  4. T. Kalland, G. Hedlund, M. Dohlsten, P. A. Lando
    Pages 81-92
  5. K. Heeg, T. Miethke, P. Bader, S. Bendigs, C. Wahl, H. Wagner
    Pages 93-106
  6. Back Matter
    Pages 135-140

About this book

Introduction

This volume of Current Topics in Microbiology and Immunology is concerned with a class of molecules that are the most potent polyclonal stimulators of T lymphocytes of several species. These molecules have been named "superantigens" because they use a mechanism of T cell stimulation closely mimicking MHC-restricted recognition of specific antigen: they act on variable parts of T cell antigen receptors and are presented by MHC class II molecules. Prototypes of these molecules are the pyrogenic exotoxins produced by S. aureus and S. pyogenes, of which the staphylococcal enterotoxins and the toxic shock syndrome toxin are the best known. Superantigens also occur endogen­ ously in mice, most notably the enigmatic Mis determinants, that have withstood characterization for nearly 20 years. Only very recently was it found that Mis is probably encoded by endogenous retroviruses. The list of candidates that are implicated as being superantigens is growing. In many cases, however, the proof that a given molecule indeed falls into this category is still missing.

Keywords

Antigen Enterotoxine Gift Infektionskrankheit T lymphocytes T-Lymphozyten Toxine, bakterielle Toxischer Schock enterotoxins toxic shock syndrome toxins, bacterial

Editors and affiliations

  • Bernhard Fleischer
    • 1
  • Hans Olov Sjögren
    • 2
  1. 1.Pathophysiology Section, First Department of MedicineUniversity of MainzMainzGermany
  2. 2.Wallenberg LaboratoryUniversity of LundLundSweden

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-50998-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 1991
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-51000-7
  • Online ISBN 978-3-642-50998-8
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site
Industry Sectors
Pharma
Health & Hospitals
Biotechnology
Consumer Packaged Goods