Kinetic Logic A Boolean Approach to the Analysis of Complex Regulatory Systems

Proceedings of the EMBO Course “Formal Analysis of Genetic Regulation”, Held in Brussels, September 6–16, 1977

  • René Thomas

Part of the Lecture Notes in Biomathematics book series (LNBM, volume 29)

Table of contents

  1. Front Matter
    Pages I-XIII
  2. Verbal description of some biological systems

  3. Naive boolean analysis

    1. Front Matter
      Pages 61-61
    2. A. Leussler, P. Van Ham
      Pages 62-85
    3. A. Leussler, P. Van Ham
      Pages 86-106
    4. P. Van Vam, J. L. Dehouck
      Pages 149-163
    5. J. Florine
      Pages 164-176
  4. More refined methods

  5. Applications (boolean and non-boolean)

    1. Front Matter
      Pages 353-353
    2. R. Thomas
      Pages 354-401
    3. Françoise Boon, André de Palma
      Pages 402-439
    4. A. Rörsch, M. A. E. Groothuis, A. M. H. Schepman
      Pages 440-463
    5. Alain Ghysen, André Farber
      Pages 464-472
    6. Jonathan M. W. Slack
      Pages 473-480
    7. J. Richelle
      Pages 502-507
  6. Back Matter
    Pages 508-510

About these proceedings


The E M B 0 course on "Formal Analysis of Genetic Regulation" A course entitled "Formal analysis of Genetic Regulation" was held at the University of Brussels from 6 to 16 September 1977 under the auspices of EMBO (European Molecular Biology Organization). As indicated by the title of the book (but not explicitly enough by the title of the course), the main emphasis was put on a dynamic analysis of systems using logical methods, that is, methods in which functions and variables take only a limited number of values - typically two. In this respect, this course was complementary to an EMBO course using continuous methods which was held some months later in Israel by Prof. Segel. People from four very different laboratories took an active part in teaching our course in Brussels : Drs Anne LEUSSLER and Philippe VAN HAM, from the Laboratory of Prof. Jean FLORINE (Laboratoire des Systemes logiques et numeriques, Faculte des Sciences appliquees, Universite Libre de Bruxelles). Dr Stuart KAUFFMAN (Dept. of Biochemistry and Biophysics, School of Medicine, Philadelphia). Prof. Gregoire NICOLlS (Service de Biophysique Theorique, Faculte des Sciences, Universite Libre de Bruxelles) and his temporary coworker Dr David RIGNEY (presently at the Center for Statistical Mechanics and Thermodynamics of the University of Texas at Austin, Texas).


Boolesche Algebra Finite Logic Molekularbiologie Regelung calculus equation

Editors and affiliations

  • René Thomas
    • 1
  1. 1.Department of Molecular Biology, Faculty of SciencesUniversity of BrusselsRhode Saint GenèseBelgium

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1979
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-09556-9
  • Online ISBN 978-3-642-49321-8
  • Series Print ISSN 0341-633X
  • Buy this book on publisher's site
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