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Investigation and Stimulation of Immunity in Cancer Patients

  • Georges Mathé
  • Roy Weiner

Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 47)

Table of contents

  1. Front Matter
    Pages I-IX
  2. Introduction

    1. G. Mathé
      Pages 1-2
  3. Investigation of Immunity in Cancer Patients

    1. Front Matter
      Pages 3-3
    2. Non Specific

      1. E. D. Thomas, L. Fass, H. D. Ochs, E. M. Mickelson, R. Storb, A. Fefer
        Pages 12-16
      2. G. W. Santos, G. M. Mullins, W. B. Bias, P. N. Anderson, K. D. Graziano, D. L. Klein et al.
        Pages 17-24
      3. E. M. Hersh, E. J. Freireich, K. B. McCredie, J. U. Gutterman, G. P. Bodey Sr., J. P. Whitecar et al.
        Pages 25-36
      4. C. M. Pinsky, A. El Domeiri, A. S. Caron, W. H. Knapper, H. F. Oettgen
        Pages 37-41
      5. M. Schneider, G. Mathé, L. Schwarzenberg, P. Pouillart, R. Weiner, J. L. Amiel et al.
        Pages 42-53
    3. Specific

      1. G. Barski, J. K. Youn, D. Le François
        Pages 54-57
      2. D. A. Clark, L. Nathanson
        Pages 67-78
      3. M. B. Widmer, Miriam Segall, F. H. Bach, Marilyn L. Bach
        Pages 79-83
      4. J. U. Gutterman, E. M. Hersh, G. Mavligit, E. J. Freireich, R. D. Rossen, W. T. Butler et al.
        Pages 97-112
      5. B. G. Leventhal, R. H. Halterman, E. B. Rosenberg, J. L. McCoy, R. B. Herberman
        Pages 113-117
      6. J. C. Leclerc, J. P. Levy, E. Gomard, F. Plata, F. M. Kourilsky
        Pages 122-126
      7. H. G. Remold
        Pages 127-128
      8. C. B. Freeman, J. S. Walker, D. Davies, H. Cocking, R. Harris
        Pages 133-139
  4. Stimulation of Immunity and Cancer Immunotherapy

    1. Front Matter
      Pages 147-147
    2. Experimental

      1. G. Mathé, M. Kamel, M. Dezfulian, O. Halle-Pannenko, C. Bourut
        Pages 149-165
      2. J. F. Petit, A. Adam, R. Ciorbaru, J. Wietzerbin-Falszpan, E. Lederer
        Pages 173-178
      3. A. Adam, R. Ciorbazru, J. F. Petit, E. Lederer
        Pages 179-182
      4. D. Jacobs, D. T. Yashphe, C. Abraham
        Pages 183-189
      5. J. Asselineau, V. Portelance
        Pages 214-220
      6. S. R. Rosenthal
        Pages 228-238
      7. B. Kouznetzova, B. Bizzini, J.-C. Chermann, F. Degrand, A.-R. Prevot, M. Raynaud
        Pages 275-293
      8. C. Pilet, F. Rothier, U. Mishra, B. Ghebrehiwet, Y. Le Garrec, L. Toujas et al.
        Pages 294-301
      9. M. M. Bortin, A. A. Rimm, E. C. Saltzstein, M. R. Shalaby, G. E. Rodey
        Pages 320-326
      10. I. Gresser
        Pages 327-329
      11. M. R. Mardiney Jr., L. Chess, C. Levy, M. Schmukler, K. Smith
        Pages 330-337

About these proceedings

Introduction

G.MATHE Institut de Cancerologie et d'Immunogenetique (INSERM et Association Claude-Bernad), H6pital Paul-Brousse and Institute Gustave-Roussy, Villejuif 20 years ago, the main, if not only object of the cancer therapist was to effect complete surgical exeresis or radiotherapeutic destruction of a local tumor, or to obtain, by means of chemotherapy, an "apparently complete regression" of a local or disseminated neoplasia. Today it is realized that (a) at the time of the operation or radiotherapy, two patients in every three carrying an apparently localized tumor have a few cancer cells outside the area where the tumor seems localized; (b) when "apparently complete regression" or even an "apparently complete remission" is induced by chemotherapy, not all the neoplastic cells have been eradicated. In both cases an imperceptible residual neoplasm persists, the growth of which will in due course make it perceptible again, giving rise to metastasis or to a systemic or localized relapse. There is thus an urgent need for a new technique capable of killing the last cell or cells. Our experiments in mice on the effectiveness of active immunotherapy, which involves the manipulation of the immune machinery, have shown that this treatment is able to kill all the cells, down to the very last cell of a given leukemia, provided that the total number of cells does not exceed a few thousand [1, 2].

Keywords

cancer cell growth immunotherapy leukemia metastasis neoplasm radiotherapy therapy tumor

Editors and affiliations

  • Georges Mathé
    • 1
  • Roy Weiner
    • 2
  1. 1.Institut de Cancérologie et d’ImmunogénétiqueVillejuifFrance
  2. 2.Children’s Cancer Research FoundationBostonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-49284-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 1974
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-49286-0
  • Online ISBN 978-3-642-49284-6
  • Series Print ISSN 0080-0015
  • Buy this book on publisher's site
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