Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development

  • Constanze Bonifer
  • Peter N. Cockerill

Part of the Epigenetics and Human Health book series (EHH)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Constanze Bonifer, Peter N. Cockerill
    Pages 1-11
  3. Nonmammalian Hematopoiesis

  4. Epigenetic Mechanisms Regulating Mammalian Hematopoietic Stem Cell Development and Function

  5. Epigenetic and Transcriptional Mechanisms Regulating Cell Fate Decisions and Blood Cell Lineage Development

  6. Epigenetic Control of Immune Cell Function

    1. Front Matter
      Pages 365-365
    2. Atsushi Onodera, Damon J. Tumes, Toshinori Nakayama
      Pages 367-382
    3. Sara Polletti, Alessia Curina, Gioacchino Natoli, Serena Ghisletti
      Pages 383-398
  7. Back Matter
    Pages 399-416

About this book


In recent years, great progress has been made in the identification of the molecular players involved in the epigenetic control of gene expression during development. The work of many laboratories has established that regulating the interplay of transcription factors with chromatin components is the major driver of cellular differentiation. Because of their single cell nature and ease of purification, much of what we have learnt about these processes in animals has been delivered based on cellular models within the hematopoietic system. The blood cell system evolved from a few simple cell types in more primitive organisms that provide oxygen transport and carry out phagocytosis into the complex hematopoietic system of mammals, containing many specialized cells types with vastly different functions, such as B cells, T cells, granulocytes, macrophages, erythrocytes, and megakaryocytes. This book describes the intricate processes involved in the development of blood cells across a range of organisms from drosophila and fish at one end, and mammals at the other end. It contains individual chapters devoted to describing the epigenetic and transcriptional mechanisms regulating hematopoiesis in the different organisms and orchestrating the differentiation of a wide variety of cell types. Different chapters describe the function of lymphocytes, macrophages and red blood cells and the molecular players, i.e. transcription factors and the epigenetic regulatory machinery driving their differentiation. Most importantly, the book not only describes normal processes, such as the rearrangements of antigen receptor genes, and the regulation of genes by various mechanisms such as DNA methylation, but also outlines what happens when these processes function abnormally to precipitate diseases such as leukemia and immune disorders.


blood cell lineage development epigenetic regulatory machinery hematopoietic stem cells immune deficiencies non-mammalian hematopoiesis transcriptional mechanisms

Editors and affiliations

  • Constanze Bonifer
    • 1
  • Peter N. Cockerill
    • 2
  1. 1.Institute of Biomedical ResearchUniversity of Birmingham Medical and Dental SciencesBirminghamUnited Kingdom
  2. 2.Institute of Biomedical ResearchUniversity of Birmingham Medical and Dental SciencesBirminghamUnited Kingdom

Bibliographic information

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