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© 2014

Cell Aging: Molecular Mechanisms and Implications for Disease

Book

Part of the SpringerBriefs in Molecular Medicine book series (BRIEFSMOME)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Christian Behl, Christine Ziegler
    Pages 1-8
  3. Christian Behl, Christine Ziegler
    Pages 9-19
  4. Christian Behl, Christine Ziegler
    Pages 21-97
  5. Christian Behl, Christine Ziegler
    Pages 99-108

About this book

Introduction

Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.

Keywords

Age-related disorders Aging biochemistry Cell aging Cellular senescence Life span extension Molecular aging matrix Molecular mechanisms of aging Nature and nurture Neurodegeration Theories of aging

Authors and affiliations

  1. 1.Institute for PathobiochemistryUniversity Medical Center of the Johannes Gutenberg University MainzMainzGermany
  2. 2.Institute for PathobiochemistryUniversity Medical Center of the Johannes Gutenberg University MainzMainzGermany

Bibliographic information

  • Book Title Cell Aging: Molecular Mechanisms and Implications for Disease
  • Authors Christian Behl
    Christine Ziegler
  • Series Title SpringerBriefs in Molecular Medicine
  • Series Abbreviated Title SpringerBriefs in Molecular Medicine
  • DOI https://doi.org/10.1007/978-3-642-45179-9
  • Copyright Information The Author(s) 2014
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Softcover ISBN 978-3-642-45178-2
  • eBook ISBN 978-3-642-45179-9
  • Series ISSN 2197-7925
  • Series E-ISSN 2197-7933
  • Edition Number 1
  • Number of Pages IX, 108
  • Number of Illustrations 2 b/w illustrations, 32 illustrations in colour
  • Topics Molecular Medicine
    Cell Biology
    Pathology
  • Buy this book on publisher's site
Industry Sectors
Biomedicine
Biotechnology
Health & Hospitals
Pharma

Reviews

From the reviews:

“It is appropriate for graduate students of the biomedical sciences, as well as scientists new to the field of aging. … This is a good introduction to the field of cell aging. … This book provides a thorough, yet brief, review of cell aging through discussions of various mechanisms of aging and age-related diseases and would be useful for a graduate student symposium or newcomers to the field of cell aging.” (Ellen Mary Andrews, Doody’s Book Reviews, April, 2014)