Voltage Gated Sodium Channels

  • Peter C. Ruben

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 221)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Colin H. Peters, Peter C. Ruben
    Pages 1-6
  3. Jonathan Silva
    Pages 33-49
  4. Mohamed Chahine, Michael E. O’Leary
    Pages 111-135
  5. Charles Antzelevitch, Vladislav Nesterenko, John C. Shryock, Sridharan Rajamani, Yejia Song, Luiz Belardinelli
    Pages 137-168
  6. David K. Jones, Peter C. Ruben
    Pages 169-181
  7. Marcel P. Goldschen-Ohm, Baron Chanda
    Pages 183-201
  8. John Gilchrist, Baldomero M. Olivera, Frank Bosmans
    Pages 203-229
  9. Cédric J. Laedermann, Isabelle Decosterd, Hugues Abriel
    Pages 231-250
  10. Ben Corry, Sora Lee, Christopher A. Ahern
    Pages 251-267
  11. Back Matter
    Pages 293-295

About this book


A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.


channelopathies drug binding selectivity structure/function relationships toxins voltage-dependent gating

Editors and affiliations

  • Peter C. Ruben
    • 1
  1. 1.Biomedical Physiology & KinesiologySimon Fraser UniversityBurnabyCanada

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