Thymic Development and Selection of T Lymphocytes

  • Thomas Boehm
  • Yousuke Takahama

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 373)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Kensuke Takada, Izumi Ohigashi, Michiyuki Kasai, Hiroshi Nakase, Yousuke Takahama
    Pages 1-17
  3. Graham Anderson, Song Baik, Jennifer E. Cowan, Amanda M. Holland, Nicholas I. McCarthy, Kyoko Nakamura et al.
    Pages 19-47
  4. Maria L. Mouchess, Mark Anderson
    Pages 69-86
  5. Shirley L. Zhang, Avinash Bhandoola
    Pages 87-111
  6. Back Matter
    Pages 131-132

About this book


The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.


Adaptive immunity Autoimmunity Cellular immunity Immunodeficiency Thymus function

Editors and affiliations

  • Thomas Boehm
    • 1
  • Yousuke Takahama
    • 2
  1. 1.Department of Developmental ImmunologyMax-Planck-Institute of Immunobiology and EpigeneticsFreiburgGermany
  2. 2.Institute for Genome Research, Division of Experimental ImmunologyUniversity of TokushimaTokushimaJapan

Bibliographic information

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