© 2014

Platelet-Rich Plasma

Regenerative Medicine: Sports Medicine, Orthopedic, and Recovery of Musculoskeletal Injuries

  • José Fábio Santos Duarte Lana
  • Maria Helena Andrade Santana
  • William Dias Belangero
  • Angela Cristina Malheiros Luzo
  • Presents a comprehensive summary of the state-of-the-art in the field of Platelet-Rich-Plasma

  • Reviews the clinical applications of platelet-rich plasma

  • Includes personal experience from professionals and researchers

  • Written by international experts in the field of platelet-rich plasma


Part of the Lecture Notes in Bioengineering book series (LNBE)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. José F. Lana, Adam Weglein, Eduardo Vicente, Amanda G. M. Perez, Ana A. Rodrigues, Ângela C. M. Luzo et al.
    Pages 1-59
  3. Amanda G. M. Perez, José F. Lana, Ana A. Rodrigues, Angela C. M. Luzo, William D. Belangero, Maria H. A. Santana
    Pages 119-138
  4. Ana A. Rodrigues, José F. Lana, Ângela C. M. Luzo, Maria H. A. Santana, Amanda G. M. Perez, D. B. Lima-Silva et al.
    Pages 139-151
  5. Adam Weglein, Steve Sampson, Danielle Aufiero
    Pages 187-201
  6. José C. Noronha
    Pages 203-213
  7. Linda Chao, Martha M. Murray, Patrick Vavken
    Pages 215-230
  8. Alberto Gobbi, Georgios Karnatzikos, Somanna Malchira, Anup Kumar
    Pages 231-236
  9. Marta Tarczyńska, Krzysztof Gaweda
    Pages 237-247
  10. David Crane, Kristin Oliver
    Pages 249-264
  11. Marko Bodor, Andrew Toy, Danielle Aufiero
    Pages 265-279
  12. André M. Cancela, José F. Lana, Joyce M. Annichino-Bizzachi, William D. Belangero, Ângela C. M. Luzo
    Pages 281-288
  13. C. H. Bittencourt, P. B. Bittencourt, O. A. L. Neto, G. C. F. Arenas
    Pages 289-313
  14. Fabricio D. Assis, Charles A. Oliveira, Thais K. Vanetti, Alexandra T. R. Luba, José F. Lana, Nelson S. A. Melo
    Pages 329-337
  15. José F. Lana, Eduardo F. Vicente, Angela B. S. D. Lana, Rodrigo K. Zogaib, Fabiano S. Magnino, Daniela B. Lima-Silva et al.
    Pages 339-360

About this book


Platelet-Rich Plasma (PRP) has gained tremendous popularity in recent years as a treatment option for specialties including Orthopedics, Dentistry, Sports Medicine, Otorhinolaryngology, Neurosurgery, Ophthalmology, Urology, Vascular, Cardiothoracic and Maxillofacial Surgery, and Veterinarian Medicine. Nowadays, PRP and Stem Cell Science have added an exciting dimension to tissue repair.

This book begins by giving the reader a broad overview of current progress as well as a discussion of the technical aspects of preparation and therapeutic use of autologous PRP. It is followed by a review of platelet structure, function and major growth factors in PRP (PDGF and TGFβ).The third chapter outlines the basic principles of biochemical cellular metabolism that increases the efficacy of PRP. Analogous to the preparation of soil for a garden, restoring cellular health should be the first consideration in Regenerative Medicine. Standardization of PRP preparation to clinical use still remains a challenging prospect. In this sense, a feasible strategy for studying PRP preparation is illustrated, which also allows to modulate and tailor the quality of PRP for further clinical applications.

The science behind PRP and stem cells, on tissue regeneration, cell proliferation and mesenchyme stem-cells are emphasized and reviewed. Various specific uses of PRP are described with detailed illustrations of various personal experiences mainly in orthopedic injuries, ligament and tend

on repair, degenerative diseases, sports medicine, chronic wound healing as well as rehabilitation aspects in tendinopathy.

Expertly written by leading scientists in the field, this book provides for beginners and experienced readers scientific fundamentals, the state of art of PRP, specific uses and personal experiences with a practical approach and reference for current trends in use. Finally, this book paves the way for future developments.


Ambulatory Therapy of Tendinopathy Ligament and Tendon Repair Osteonecrosis of the Femoral Head Plasma and Tissue Engineering Platelet-rich Plasma Recovery of Musculoskeletal Injuries Regenerative Medicine

Editors and affiliations

  • José Fábio Santos Duarte Lana
    • 1
  • Maria Helena Andrade Santana
    • 2
  • William Dias Belangero
    • 3
  • Angela Cristina Malheiros Luzo
    • 4
  1. 1.Research Institute of Sports MedicineOrthopedics and Regeneration - iMORUberabaBrazil
  2. 2.Department of Biotechnological ProcessesUniversity of CampinasCampinasBrazil
  3. 3.Department of Orthopaedic and TraumatologyUniversity of CampinasCampinasBrazil
  4. 4.Haematology and Hemotherapy CenterState University of CampinasCampinasBrazil

Bibliographic information

  • Book Title Platelet-Rich Plasma
  • Book Subtitle Regenerative Medicine: Sports Medicine, Orthopedic, and Recovery of Musculoskeletal Injuries
  • Editors José Fábio Santos Duarte Lana
    Maria Helena Andrade Santana
    William Dias Belangero
    Angela Cristina Malheiros Luzo
  • Series Title Lecture Notes in Bioengineering
  • Series Abbreviated Title Lect.Notes Bioengineering
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2014
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Engineering Engineering (R0)
  • Hardcover ISBN 978-3-642-40116-9
  • Softcover ISBN 978-3-662-51027-8
  • eBook ISBN 978-3-642-40117-6
  • Series ISSN 2195-271X
  • Series E-ISSN 2195-2728
  • Edition Number 1
  • Number of Pages XVII, 360
  • Number of Illustrations 12 b/w illustrations, 77 illustrations in colour
  • Topics Biomedical Engineering and Bioengineering
    Cytokines and Growth Factors
    Sports Medicine
    Biomedicine, general
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Consumer Packaged Goods
Materials & Steel


“Black-and-white and full-color charts, micrographs, photos, tables, x-rays and other types of images are used throughout the book to make it easier for the student or practitioner to understand what is presented in the text portion of the chapters. Books on the subject of platelet-rich plasma are rare, and this one is quite comprehensive and thorough in its coverage. This is an excellent addition to the library of anyone interested in learning more about, or practicing regenerative medicine.” (Nano Khilnani, Biz India Online News,, April, 2015)

“The focus of this wonderful book is on the foundation, impact, application, and future of platelet-rich plasma (PRP). … A broad audience of primary care physicians and surgeons, as well as researchers and clinicians, will benefit from the information and direction that this book provides. … it is well organized and provides a great deal of valuable information that is easy to follow and retrieve. This is an excellent, foundational book on PRP.” (Mark R. Hutchinson, Doody’s Book Reviews, February, 2014)