Challenges and Opportunities for Respiratory Syncytial Virus Vaccines

  • Larry J. Anderson
  • Barney S. Graham

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 372)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Virology, Pathogenesis, and Clinical and Epidemiological Features of Disease

    1. Front Matter
      Pages 1-1
    2. Peter L. Collins, Rachel Fearns, Barney S. Graham
      Pages 3-38
    3. Caroline B. Hall, Eric A. F. Simőes, Larry J. Anderson
      Pages 39-57
    4. Jason S. McLellan, William C. Ray, Mark E. Peeples
      Pages 83-104
    5. Matthew T. Lotz, Martin L. Moore, R. Stokes Peebles Jr.
      Pages 105-118
  3. Host Response to Infection and Genetics of Disease

    1. Front Matter
      Pages 119-119
    2. Eun Hwa Choi, Hoan Jong Lee, Stephen J. Chanock
      Pages 121-137
    3. Sumanta Mukherjee, Nicholas W. Lukacs
      Pages 139-154
    4. Steven M. Varga, Thomas J. Braciale
      Pages 155-171
    5. Ralph A. Tripp, Asuncion Mejias, Octavio Ramilo
      Pages 193-209
    6. Allison M. W. Malloy, Ann R. Falsey, Tracy J. Ruckwardt
      Pages 211-231
  4. Vaccine Platforms and Treatment Options

    1. Front Matter
      Pages 233-233
    2. Helen Y. Chu, Janet A. Englund
      Pages 235-258
    3. Ruth A. Karron, Ursula J. Buchholz, Peter L. Collins
      Pages 259-284
    4. Rebecca J. Loomis, Philip R. Johnson
      Pages 307-324
  5. Animal and Tissue Culture Models of Infection

  6. Conclusions

    1. Front Matter
      Pages 389-389
    2. Barney S. Graham, Larry J. Anderson
      Pages 391-404
  7. Back Matter
    Pages 405-409

About this book


Although respiratory syncytial virus (RSV) has been a high priority for vaccine development for over 50 years now, still no vaccine is available and none has yet demonstrated sufficient promise to move to licensure. The success of RSV immune prophylaxis and the availability of ever more powerful tools to study the immune response and pathogenesis of disease, combined with the ability to construct a wide variety of vaccines using different vaccine platforms, give us grounds to believe that an RSV vaccine is within reach. This book brings together in one source what is currently known about the virus: its clinical and epidemiologic features; the host response and pathogenesis of the disease; vaccines, vaccine platforms, and treatment; and animal and tissue culture models of RSV infection. It is designed to organize the critical information relevant to RSV vaccine development, facilitate the assimilation of data, and speed progress toward producing a safe and effective vaccine.


Epidemiology Pathogenesis RSV Virology Virus infection

Editors and affiliations

  • Larry J. Anderson
    • 1
  • Barney S. Graham
    • 2
  1. 1.Department of Pediatrics and Children's Healthcare of AtlantaEmory UniversityAtlantaUSA
  2. 2.Vaccine Research CenterNIH Natl. Inst. of Allergy & Infect. Dis.BethesdaUSA

Bibliographic information

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