Systems Biology of Metabolic and Signaling Networks

Energy, Mass and Information Transfer

  • Miguel A. Aon
  • Valdur Saks
  • Uwe Schlattner

Part of the Springer Series in Biophysics book series (BIOPHYSICS, volume 16)

Table of contents

  1. Front Matter
    Pages i-x
  2. Introduction

  3. Systems Biology of Signaling Networks

    1. Front Matter
      Pages 37-37
    2. Hans V. Westerhoff, Samrina Rehman, Fred C. Boogerd, Nilgun Yilmaz, Malkhey Verma
      Pages 39-62
    3. Song Zhang, Emirhan Nemutlu, Andre Terzic, Petras Dzeja
      Pages 145-162
  4. Systems Biology of Cellular Structures and Fluxes

    1. Front Matter
      Pages 163-163
    2. Ildefonso Mtz. de la Fuente
      Pages 179-211
    3. Alvaro Marín-Hernández, Sayra Y. López-Ramírez, Juan Carlos Gallardo-Pérez, Sara Rodríguez-Enríquez, Rafael Moreno-Sánchez, Emma Saavedra
      Pages 213-239
  5. Systems Biology of Organ Function

    1. Front Matter
      Pages 241-241
    2. Valdur Saks, Uwe Schlattner, Malgorzata Tokarska-Schlattner, Theo Wallimann, Rafaela Bagur, Sarah Zorman et al.
      Pages 261-320
  6. Systems Biology of Microorganisms

    1. Front Matter
      Pages 321-321
    2. Douglas B. Murray, Cornelia Amariei, Kalesh Sasidharan, Rainer Machné, Miguel A. Aon, David Lloyd
      Pages 323-349
    3. Johannes Geiselmann
      Pages 351-367
  7. Back Matter
    Pages 369-375

About this book


Systems Biology represents a new paradigm aiming at a whole-organism-level understanding of biological phenomena, emphasizing interconnections and functional interrelationships rather than component parts. The study of network properties, and how they control and regulate behavior from the cellular to organism level, constitutes a main focus of Systems Biology. This book addresses from a novel perspective a major unsolved biological problem: understanding how a cell works and what goes wrong in pathology. The task undertaken by the authors is in equal parts conceptual and methodological, integrative and analytical, experimental and theoretical, qualitative and quantitative, didactic and comprehensive. Essentially, they unravel the spatio-temporal unfolding of interacting mass-energy and information networks at the cellular and organ levels, as well as its modulation through activation or repression by signaling networks to produce a certain phenotype or (patho)physiological response.

Starting with the historical roots, in thirteen chapters this work explores the Systems Biology of signaling networks, cellular structures and fluxes, organ and microorganism functions. In doing so, it establishes the basis of a 21st century approach to biological complexity.


cell function energy transfer metabolic networks signaling networks systems biology

Editors and affiliations

  • Miguel A. Aon
    • 1
  • Valdur Saks
    • 2
  • Uwe Schlattner
    • 3
  1. 1.School of MedicineJohns Hopkins UniversityBaltimoreUSA
  2. 2.Laboratory of Fundamental and Applied BiInserm U1055 and University Joseph Fourier, GrenobleGrenoble cedex 9France
  3. 3.Laboratory of Fundamental and Applied BiInserm U1055 and University Joseph Fourier, GrenobleGrenoble cedex 9France

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2014
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-38504-9
  • Online ISBN 978-3-642-38505-6
  • Series Print ISSN 0932-2353
  • Series Online ISSN 1868-2561
  • Buy this book on publisher's site
Industry Sectors
Consumer Packaged Goods