© 2013

Disruption of Protein-Protein Interfaces

In Search of New Inhibitors

  • Stefano Mangani
  • Provides an overview of the present state and future perspectives of drug discovery at protein-protein interfaces

  • Gives details of both computational and experimental tools used in the field

  • Gives positive examples of drug-like molecules effective in interacting at protein-protein interfaces


Table of contents

  1. Front Matter
    Pages i-vii
  2. Laura Bettinetti, Matteo Magnani, Alessandro Padova
    Pages 1-29
  3. Stefania Ferrari, Federica Pellati, Maria Paola Costi
    Pages 31-60
  4. Simon Cross, Massimo Baroni, Francesco Ortuso, Stefano Alcaro, Gabriele Cruciani
    Pages 61-82
  5. Rebecca Del Conte, Daniela Lalli, Paola Turano
    Pages 83-111
  6. Back Matter
    Pages 159-161

About this book


"Disruption of Protein-Protein Interfaces" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces, as well as including details of experimental and computational tools to tackle the subject, and highlighting the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the development of useful new drugs. Consequently, in recent years great effort has been dedicated to unveiling the molecular details of protein-protein interfaces by structural techniques e.g. X-ray diffraction, NMR spectroscopy. This book, written and edited by leaders in the field, provides examples from the literature of successes and failures to develop drug-like molecules effective in interacting at protein-protein interfaces.


Dissociative inhibition model Drug discovery Inhibitors design Inhibitors of protein-protein interactions Interface directed inhibitors Ligand binding sites at protein interfaces Protein-protein interfaces as drug targets Quaternary structure inhibitors

Editors and affiliations

  • Stefano Mangani
    • 1
  1. 1., Department of Biotechnology, Chemistry aUniversity of SienaSienaItaly

About the editors

Stefano Mangani has been professor of general and inorganic chemistry at the University of Siena since 1994. His main field of research is bioinorganic chemistry and structural biology and he currently focuses on the role of metal ions in metalloenzyme catalysis and in metalloproteins, with particular emphasis on the chemistry occurring at the metal sites as revealed by accurate structural data. Professor Mangani is regularly invited to speak at international conferences and seminars. He is the author of over 140 publications in international scientific journals and book series and has also written a general and inorganic university textbook and a web-course on general chemistry.

Bibliographic information

  • Book Title Disruption of Protein-Protein Interfaces
  • Book Subtitle In Search of New Inhibitors
  • Editors Stefano Mangani
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2013
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Chemistry and Materials Science Chemistry and Material Science (R0)
  • Hardcover ISBN 978-3-642-37998-7
  • Softcover ISBN 978-3-642-43389-4
  • eBook ISBN 978-3-642-37999-4
  • Edition Number 1
  • Number of Pages VII, 161
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Organic Chemistry
  • Buy this book on publisher's site
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