Intrinsic Immunity

  • Bryan R. Cullen

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 371)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Eric W. Refsland, Reuben S. Harris
    Pages 1-27
  3. Stuart J. D. Neil
    Pages 67-104
  4. György Szittya, József Burgyán
    Pages 153-181
  5. Arabinda Nayak, Michel Tassetto, Mark Kunitomi, Raul Andino
    Pages 183-200
  6. Karyn McFadden, Micah A. Luftig
    Pages 229-257
  7. Back Matter
    Pages 259-262

About this book


Recent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin and SAMHD1, which were initially discovered by researchers studying HIV-1. Furthermore, the role of RNA interference in antiviral defense in plants and invertebrates, as well as the interplay between microRNAs and viruses in mammalian cells, are analysed. One chapter discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors drive both pathogen and host evolution, and finally the emerging evidence that DNA damage response proteins restrict infection by DNA viruses is highlighted.



Antiviral immunity DNA damage response DNA viruses MicroRNA RNA interference Retroviruses

Editors and affiliations

  • Bryan R. Cullen
    • 1
  1. 1.Center for Virology, Department of Molecular Genetics and MicDuke University Medical CenterDurhamUSA

Bibliographic information

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