Systems Biology

  • Michael G. Katze

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 363)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Alan Diercks, Alan Aderem
    Pages 1-19
  3. Charles Ansong, Brooke L. Deatherage, Daniel Hyduke, Brian Schmidt, Jason E. McDermott, Marcus B. Jones et al.
    Pages 21-41
  4. James Galagan, Anna Lyubetskaya, Antonio Gomes
    Pages 43-68
  5. Robert E. Palermo, Deborah H. Fuller
    Pages 87-116
  6. Sai S. Duraisingham, Nadine Rouphael, Mary M. Cavanagh, Helder I. Nakaya, Jorg J. Goronzy, Bali Pulendran
    Pages 117-142
  7. I-Ming Wang, David J. Stone, David Nickle, Andrey Loboda, Oscar Puig, Christopher Roberts
    Pages 169-199
  8. Kelly F. Benedict, Douglas A. Lauffenburger
    Pages 201-233
  9. Arndt G. Benecke
    Pages 235-259
  10. Back Matter
    Pages 261-263

About this book


In this volume, a wide-ranging series of reviews reveal how systems biology—a holistic and inter-disciplinary approach requiring the combined talents of biologists, mathematicians, and computer scientists—is changing the face of infectious disease research. Leading experts discuss how the use of high-throughput and computational approaches are generating exciting—and often unexpected—new insights into the microbial-host interactions of a variety of bacterial and viral pathogens, including Salmonella, Yersinia, Mycobacterium, influenza virus, human and simian immunodeficiency virus, and hepatitis C virus. Additional chapters focus on systems approaches to innate immunity, intra- and inter-cellular signaling, biomarker discovery, and the evaluation and rational development of improved vaccines. Systems biology has both been hailed as a paradigm shift that will revolutionize biological science and criticized as overly expensive and complex. While the truth no doubt lies somewhere in between, the approach is yielding increasingly detailed and comprehensive views of biological systems and processes, including those that dictate the host response to infection and disease outcome. Systems Biology of Infectious Disease is highly informative reading for investigators already engaged in systems biology research as well as for those scientists and clinicians who may be seeking an introduction to the field.


"inflammatome" signature biomarker identification host-pathogen genome politics immune cell signaling mycobacterium tuberculosis systems vaccinology

Editors and affiliations

  • Michael G. Katze
    • 1
  1. 1., Department of MicrobiologyUniversity of Washington at SeattleSeattleUSA

Bibliographic information

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