© 2013

Novel Synthetic Chemistry of Ureas and Amides


Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Marc Hutchby
    Pages 1-35
  3. Marc Hutchby
    Pages 45-55
  4. Marc Hutchby
    Pages 57-70
  5. Marc Hutchby
    Pages 71-88
  6. Marc Hutchby
    Pages 89-94
  7. Marc Hutchby
    Pages 95-160
  8. Back Matter
    Pages 161-166

About this book


In this thesis, the author investigates the chemistry and application of molecules containing urea and amide bonds. These bonds are some of the strongest known and are fundamental to biological processes. The author describes his discovery that sterically hindered ureas undergo solvolysis at room temperature under neutral conditions. This is a remarkable finding, since ureas are inert under these conditions and a general rule of chemistry is that hindered substrates are less reactive. Remarkably, the author translates these results to the correspondingly sterically hindered amides. This thesis has resulted in a number of outstanding publications in high profile journals. The unique method for breaking urea and amide bonds developed in this study is likely to have far reaching consequences for biological protein manipulation.


Amide Hydrolysis C-H Activation Mild Solvolysis Neutral Solvolysis Palladium Catalysed Carbonylation Rapid Solvolysis Urea Hydrolysis

Authors and affiliations

  1. 1., Thomas Graham HouseRoyal Society of ChemistryCambridgeUnited Kingdom

Bibliographic information

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