Sex and Gender Differences in Pharmacology

  • Vera Regitz-Zagrosek

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 214)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Sex Differences in Mechanisms of Disease

    1. Front Matter
      Pages 1-1
    2. Vera Regitz-Zagrosek, Ute Seeland
      Pages 3-22
    3. S. Mahmoodzadeh, D. Fliegner, E. Dworatzek
      Pages 23-48
    4. Elisabetta Straface, Lucrezia Gambardella, Marta Brandani, Walter Malorni
      Pages 49-65
  3. Sex Differences in Pharmacokinetics, in Drug Development and Use

    1. Front Matter
      Pages 89-89
    2. Ilaria Spoletini, Cristiana Vitale, Walter Malorni, Giuseppe M C Rosano
      Pages 91-105
    3. Flavia Franconi, Ilaria Campesi, Stefano Occhioni, Paola Antonini, Michael F. Murphy
      Pages 107-126
    4. Gerd Glaeske, Cornelia Gerdau-Heitmann, Friederike Höfel, Christel Schicktanz
      Pages 149-167
    5. I. Gouni-Berthold, H. K. Berthold
      Pages 183-208
  4. Sex Differences in Different Therapeutic Areas

    1. Front Matter
      Pages 209-209
    2. Ute Seeland, Vera Regitz-Zagrosek
      Pages 211-236
    3. Junko Kurokawa, Masami Kodama, Tetsushi Furukawa, Colleen E. Clancy
      Pages 237-263
    4. Ilaria Campesi, Marco Fois, Flavia Franconi
      Pages 265-278
    5. Alexandra Kautzky-Willer, Rosa Lemmens-Gruber
      Pages 307-340
    6. Alois Gessl, Rosa Lemmens-Gruber, Alexandra Kautzky-Willer
      Pages 341-359
    7. Alois Gessl, Rosa Lemmens-Gruber, Alexandra Kautzky-Willer
      Pages 361-386
    8. Verena Benz, Ulrich Kintscher, Anna Foryst-Ludwig
      Pages 387-410
    9. Oliver Schmetzer, Anne Flörcken
      Pages 411-442
    10. Svitlana Demyanets, Johann Wojta
      Pages 443-472
    11. Ulrike Voß, Anne Lewerenz, Karen Nieber
      Pages 473-497
    12. A. Cleve, K.-H. Fritzemeier, B. Haendler, N. Heinrich, C. Möller, W. Schwede et al.
      Pages 543-587
  5. Back Matter
    Pages 589-600

About this book


This is the very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioeconomic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug development, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed.


adverse effects drug development pharmacodynamics pharmacokinetics sex/gender

Editors and affiliations

  • Vera Regitz-Zagrosek
    • 1
  1. 1.Institute of Gender in Medicine (GiM), Center for Cardiovascular Research (CCR)Charité - Universitätsmedizin BerlinBerlinGermany

Bibliographic information

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