© 2012

Molecular Aspects of Hematologic Malignancies

Diagnostic Tools and Clinical Applications

  • Michal Witt
  • Malgorzata Dawidowska
  • Tomasz Szczepanski
  • Up-to-date information on the molecular basis of selected hematologic disorders

  • Practical reference for molecular laboratory procedures

  • Of interest to clinical oncologists and hematologists as well as to graduates in molecular medicine, human genetics and laboratory medicine


Part of the Principles and Practice book series (PRINCIPLES)

Table of contents

  1. Front Matter
    Pages i-x
  2. Molecular Biology of Selected Hemato-oncologic Diseases

    1. Front Matter
      Pages 1-1
    2. Małgorzata Dawidowska, Monika D. Kraszewska, Katarzyna Derwich, Tomasz Szczepański
      Pages 3-28
    3. Agata A. Filip, Marta Libura, Sebastian Giebel, Olga Haus
      Pages 29-53
    4. Przemysław Juszczyński, Krzysztof Warzocha
      Pages 55-70
    5. Anna Dmoszyńska, Norbert Grząśko
      Pages 71-84
    6. Anton W. Langerak, Yorick Sandberg
      Pages 85-101
    7. Tomasz Sacha, Kajetana Foryciarz, Aleksander B. Skotnicki
      Pages 103-115
    8. Francesc Solé
      Pages 117-127
    9. Andrzej Hellmann, Maria Bieniaszewska, Witold Prejzner, Aleksandra Leszczyńska
      Pages 129-140
  3. Diagnostics and Monitoring of Therapy of Hemato-oncologic Diseases

    1. Front Matter
      Pages 141-141
    2. Łukasz Sędek, Juan Flores-Montero, Joanna Bulsa, Susana Barrena, Julia Almeida, Alberto Orfao et al.
      Pages 143-160
    3. Olga Haus, Anna Poluha, Katarzyna Skonieczka
      Pages 161-181
    4. Tomasz Szczepański, Małgorzata Dawidowska, Katarzyna Derwich
      Pages 183-197
    5. Przemysław Juszczyński, Bjoern Chapuy, Małgorzata Szczepaniak, Krzysztof Warzocha
      Pages 199-214
  4. Molecular Procedures Involved in Hematopoietic Stem Cell Transplantation

    1. Front Matter
      Pages 215-215
    2. Małgorzata Dawidowska, Katarzyna Guz, Ewa Brojer, Jacek Wachowiak, Michał Witt
      Pages 255-273
    3. Małgorzata Dawidowska, Katarzyna Derwich, Tomasz Szczepański
      Pages 275-284

About this book


This book provides a state-of-the-art approach to the molecular basis of hematologic diseases and its translation into improved diagnostics and novel therapeutic strategies. Several representative hemato-oncologic malignancies are analyzed in detail: acute lymphoblastic leukemia, acute myeloid leukemia, B-cell Non-Hodgkin lymphomas, multiple myeloma, chronic lymphocytic leukemia, chronic myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms. Experts in the field describe the molecular methods applied for modern diagnostics and therapies, such as hematopoietic stem cell transplantation, donor recipient matching, banking of biological material, analyses of post-transplant chimerism, and minimal residual disease monitoring. The volume concludes with an extensive section comprising thorough step-by-step protocols of molecular techniques in hematology, all of them validated in the authors’ own laboratories.



hematology leukemia minimal residual disease molecular biology oncology stem cell transplantation

Editors and affiliations

  • Michal Witt
    • 1
  • Malgorzata Dawidowska
    • 2
  • Tomasz Szczepanski
    • 3
  1. 1.International Institute of Molecular andWarszawaPoland
  2. 2., Institute of Human GeneticsPolish Academy of SciencesPoznanPoland
  3. 3., Department of Pediatric HematologySilesian Academy of MedicineZabrzePoland

Bibliographic information

Industry Sectors
Health & Hospitals


From the reviews:

“This book describes current diagnostic tools and clinical procedures used for hematological malignancies. … The goal was to meet the needs of both clinical hematologists who treat patients with leukemia, lymphoma, and/or multiple myeloma and those who study these diseases in the laboratory. … an excellent review of molecular biology for specific hematological malignancies and disorders. It also covers important molecular testing techniques that are commonly used in the diagnosis, management, and surveillance of these malignancies. … a valuable addition to any hematologist’s library.” (John Patrick Galvin, Doody’s Review Service, October, 2012)