© 2012


Mechanisms and Clinical Implications of Nevus Development

  • Ashfaq A. Marghoob
  • A detailed update on current knowledge of nevogenesis

  • Presents the latest evidence from a wide variety of studies

  • Will help practicing physicians to manage patients with a variety of nevi and assist researchers in the field of nevogenesis and melanomagenesis


Table of contents

  1. Front Matter
    Pages i-viii
  2. Mark E. Burnett, Ashfaq A. Marghoob, Alon Scope
    Pages 1-23
  3. Iris Zalaudek, Caterina Longo, Cinzia Ricci, Giuseppe Albertini, Giuseppe Argenziano
    Pages 25-41
  4. Harald Kittler
    Pages 43-47
  5. Iris Zalaudek, Alon Scope, Giuseppe Argenziano, Caterina Longo, Simonetta Piana, Caterina Carticalà et al.
    Pages 49-57
  6. Barbara De Pace, Barbara Ferrari, Giovanni Pellacani, Barbara Predieri, Lorenzo Iughetti, Leonardo Veneziano et al.
    Pages 59-67
  7. Tracey Liebman, Natalia Jaimes Lopez, Stephen W. Dusza
    Pages 69-72
  8. Miguel Reyes-Múgica, Mark Beckwith, Heather C. Etchevers
    Pages 73-97
  9. Andrew L. Ross, Margaret I. Sanchez, James M. Grichnik
    Pages 99-110
  10. Andrew L. Ross, Margaret I. Sanchez, James M. Grichnik
    Pages 111-115
  11. Andrew L. Ross, Margaret I. Sanchez, James M. Grichnik
    Pages 117-126
  12. Stephen W. Dusza, Mark E. Burnett
    Pages 127-135
  13. Alexander Marzuka-Alcalá, Hensin Tsao
    Pages 137-144
  14. Vitaly Terushkin, Ashfaq A. Marghoob, Alon Scope, Rainer Hofmann-Wellenhof
    Pages 145-153
  15. Back Matter
    Pages 155-160

About this book


Paul Gerson Unna’s “Abtropfung” theory that nevi develop through migration of nevus cells from the epidermis to the dermis prevailed for almost a century until the “Hochsteigerung” theory postulated the reverse pattern of migration based on newly acquired observations from histopathology and studies of embryogenesis. Most recently, however, new insights gained from epidemiology, cross-sectional and longitudinal studies of nevi, dermoscopy and confocal microscopy, and cellular and molecular studies have brought into question both of the aforementioned theories. This book provides a comprehensive guide to current knowledge about nevogenesis by presenting these latest advances and in addition discusses issues yet to be resolved. It will assist practicing physicians in effectively managing patients with a variety of nevi and will also be of great value to researchers in the field. Importantly, since nevi are associated with an increased risk of melanoma, understanding nevogenesis may help to unravel some of the mysteries of melanomagenesis.


Growth and evolution of nevi Involution Melanoma Nevus development Senescence

Editors and affiliations

  • Ashfaq A. Marghoob
    • 1
  1. 1.Skin Cancer Center, Hauppauge Dermatology SectionMemorial Sloan KetteringHauppaugeUSA

About the editors

Ashfaq Marghoob, MD, graduated in 1987 from the School of Medicine, State University of New York at Stony Brook, where he later performed his Residency in Dermatology. He was appointed Clinical Assistant Professor in the Department of Dermatology at Stony Brook in 1995 and Associate Professor of Dermatology in 2005. Dr. Marghoob currently works at the Memorial Hospital for Cancer and Allied Diseases and is an Associate Member of Memorial Sloan-Kettering Cancer Center. He has been the recipient of various honors and awards, including a Physician’s Recognition Award from the American Medical Association, and is included in The Best Doctors in America. Dr. Marghoob has been the lead author or co-author of more than 180 articles in peer-reviewed journals and many book chapters. He is the co-author of the Handbook of Dermoscopy (Taylor & Francis 2006) and co-editor of an Atlas of Dermoscopy (Taylor & Francis 2005).

Bibliographic information

  • Book Title Nevogenesis
  • Book Subtitle Mechanisms and Clinical Implications of Nevus Development
  • Editors Ashfaq A. Marghoob
  • DOI
  • Copyright Information Springer- Verlag Berlin Heidelberg 2012
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-642-28396-3
  • Softcover ISBN 978-3-662-50736-0
  • eBook ISBN 978-3-642-28397-0
  • Edition Number 1
  • Number of Pages VIII, 160
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Dermatology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology
Consumer Packaged Goods


From the reviews:

“The purpose is to provide an update on how nevi are formed, their evolution, and factors that influence their development. I haven’t read any other book that addresses this subject in this depth. The authors do a superb job. … This should be required reading for all dermatology residents and dermatologists out of training.” (Patricia Wong, Doody’s Book Reviews, June, 2013)