Mechanisms and Clinical Implications of Nevus Development

  • Ashfaq A. Marghoob

Table of contents

  1. Front Matter
    Pages i-viii
  2. Mark E. Burnett, Ashfaq A. Marghoob, Alon Scope
    Pages 1-23
  3. Iris Zalaudek, Caterina Longo, Cinzia Ricci, Giuseppe Albertini, Giuseppe Argenziano
    Pages 25-41
  4. Harald Kittler
    Pages 43-47
  5. Iris Zalaudek, Alon Scope, Giuseppe Argenziano, Caterina Longo, Simonetta Piana, Caterina Carticalà et al.
    Pages 49-57
  6. Barbara De Pace, Barbara Ferrari, Giovanni Pellacani, Barbara Predieri, Lorenzo Iughetti, Leonardo Veneziano et al.
    Pages 59-67
  7. Tracey Liebman, Natalia Jaimes Lopez, Stephen W. Dusza
    Pages 69-72
  8. Miguel Reyes-Múgica, Mark Beckwith, Heather C. Etchevers
    Pages 73-97
  9. Andrew L. Ross, Margaret I. Sanchez, James M. Grichnik
    Pages 99-110
  10. Andrew L. Ross, Margaret I. Sanchez, James M. Grichnik
    Pages 111-115
  11. Andrew L. Ross, Margaret I. Sanchez, James M. Grichnik
    Pages 117-126
  12. Stephen W. Dusza, Mark E. Burnett
    Pages 127-135
  13. Alexander Marzuka-Alcalá, Hensin Tsao
    Pages 137-144
  14. Vitaly Terushkin, Ashfaq A. Marghoob, Alon Scope, Rainer Hofmann-Wellenhof
    Pages 145-153
  15. Back Matter
    Pages 155-160

About this book


Paul Gerson Unna’s “Abtropfung” theory that nevi develop through migration of nevus cells from the epidermis to the dermis prevailed for almost a century until the “Hochsteigerung” theory postulated the reverse pattern of migration based on newly acquired observations from histopathology and studies of embryogenesis. Most recently, however, new insights gained from epidemiology, cross-sectional and longitudinal studies of nevi, dermoscopy and confocal microscopy, and cellular and molecular studies have brought into question both of the aforementioned theories. This book provides a comprehensive guide to current knowledge about nevogenesis by presenting these latest advances and in addition discusses issues yet to be resolved. It will assist practicing physicians in effectively managing patients with a variety of nevi and will also be of great value to researchers in the field. Importantly, since nevi are associated with an increased risk of melanoma, understanding nevogenesis may help to unravel some of the mysteries of melanomagenesis.


Growth and evolution of nevi Involution Melanoma Nevus development Senescence

Editors and affiliations

  • Ashfaq A. Marghoob
    • 1
  1. 1.Skin Cancer Center, Hauppauge Dermatology SectionMemorial Sloan KetteringHauppaugeUSA

Bibliographic information

  • DOI
  • Copyright Information Springer- Verlag Berlin Heidelberg 2012
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-642-28396-3
  • Online ISBN 978-3-642-28397-0
  • Buy this book on publisher's site
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Internal Medicine & Dermatology
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