© 2012

Fragment-Based Drug Discovery and X-Ray Crystallography

  • Thomas G. Davies
  • Marko Hyvönen

Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 317)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Daniel A. Erlanson
    Pages 1-32
  3. Thomas G. Davies, Ian J. Tickle
    Pages 33-59
  4. Stephen Roughley, Lisa Wright, Paul Brough, Andrew Massey, Roderick E. Hubbard
    Pages 61-82
  5. Daniel F. Wyss, Yu-Sen Wang, Hugh L. Eaton, Corey Strickland, Johannes H. Voigt, Zhaoning Zhu et al.
    Pages 83-114
  6. Eugene Valkov, Tim Sharpe, May Marsh, Sandra Greive, Marko Hyvönen
    Pages 145-179
  7. Joseph D. Bauman, Disha Patel, Eddy Arnold
    Pages 181-200
  8. Back Matter
    Pages 223-225

About this book


D. A. Erlanson Introduction to Fragment-Based Drug Discovery T. G. Davies Ian J. Tickle Fragment Screening Using X-Ray Crystallography S. Roughley L. Wright P. Brough A. Massey R. E. Hubbard Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening D. F. Wyss Y.-S. Wang H. L. Eaton C. Strickland J.s H. Voigt Z. Zhu A. W. Stamford Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors M. Hennig A. Ruf Walter HuberCombining Biophysical Screening and X-Ray Crystallography for Fragment-Based Drug Discovery E. Valkov T. Sharpe M. Marsh Sa. Greive M. Hyvönen Targeting Protein–Protein Interactions and Fragment-Based Drug Discovery J.h D. Bauman D. Patel E. Arnold Fragment Screening and HIV Therapeutics D. Rognan Fragment-Based Approaches and Computer-Aided Drug Discovery


Astex Pharmaceuticals Biophysical Screening Computer Aided Drug Discovery Fragment Screening Fragment-Based Drug Discovery Hsp90 Inhibitors Protein-Protein Interactions Review Selective BACE-1 Inhibitors Virtual Screening

Editors and affiliations

  • Thomas G. Davies
    • 1
  • Marko Hyvönen
    • 2
  1. 1.Astex PharmaceuticalsCambridgeUnited Kingdom
  2. 2., Department of BiochemistryUniversity of CambridgeCambridgeUnited Kingdom

Bibliographic information

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