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Heteroaromatic Lipoxin A4 Analogues

Synthesis and Biological Evaluation

  • Colm Duffy

Part of the Springer Theses book series (Springer Theses)

About this book

Introduction

In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in  the synthesis of further heteroaromatic analogues for biological evaluation.

Keywords

Aromatic Lipoxin A4 analogues Lipoxin analogues phagocytosis of apoptotic PMN's Stable Lipoxins Zirconium tetrachloride protection/deprotection methodology pro-inflammatory cytokine

Authors and affiliations

  • Colm Duffy
    • 1
  1. 1.MRC Laboratory of Molecular BiologyCambridgeUnited Kingdom

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