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Intradermal Immunization

  • Marcel B.M.┬áTeunissen

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 351)

Table of contents

  1. Front Matter
    Pages i-x
  2. Y. C. Kim, C. Jarrahian, D. Zehrung, S. Mitragotri, M. R. Prausnitz
    Pages 77-112
  3. N. Romani, V. Flacher, C. H. Tripp, F. Sparber, S. Ebner, P. Stoitzner
    Pages 113-138
  4. A. H. E. Roukens, L. B. S. Gelinck, L. G. Visser
    Pages 159-179
  5. D. Oosterhoff, B. J. R. Sluijter, B. N. Hangalapura, T. D. de Gruijl
    Pages 181-220
  6. K. Oosterhuis, J. H. van den Berg, T. N. Schumacher, J. B. A. G. Haanen
    Pages 221-250
  7. Back Matter
    Pages 251-253

About this book

Introduction

Despite the impressive success of current vaccine programs, there remains a need to improve the effectiveness of current vaccines. A more powerful and longer lasting immune response induced by smaller and fewer doses of vaccine is an exciting challenge. Improvement of effectiveness also enables induction of protective immunity in populations that respond poorly to vaccination, for example elderly or immune-compromised individuals.

 This volume of Current Topics in Microbiology and Immunology covers diverse topics related to intradermal immunization. The volume starts with a basic overview of murine and human skin dendritic cell network, respectively, and their role in immunity, as well as an extensive description of the immunobiology of the skin. The next chapter describes the state-of-the-art on delivery systems especially designed for intradermal vaccination. The remaining chapters highlight the effectiveness of intradermal immunization in experimental animal models or in clinical practice, all supporting the view that intradermal immunization is at least as good as other immunization routes. Keeping in mind that current vaccines are not specially designed for intradermal immunization, but show comparable efficiency even at reduced dosages, this underlines the great potential for the skin as a vaccination site Hopefully, the overview in this volume will encourage vaccine designers to focus on this promising immunization route, and in addition, to inspire them to develop vaccines that are especially optimized for intradermal immunization.

Keywords

DNA tattooing Rabies vaccination human epidermal Langerhans cells influenza vaccination intradermal Rabies vaccination intradermal immunization skin dendritic cells yellow fever vaccination

Editors and affiliations

  • Marcel B.M.┬áTeunissen
    • 1
  1. 1., Department of DermatologyUniversity of Amsterdam, Academic MedicaAmsterdamNetherlands

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-23690-7
  • Copyright Information Springer-Verlag Berlin Heidelberg 2012
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-23689-1
  • Online ISBN 978-3-642-23690-7
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site
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Biotechnology