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© 2012

Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors

Book

Part of the Advances in Anatomy, Embryology and Cell Biology book series (ADVSANAT, volume 211)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Inge Brouns, Isabel Pintelon, Jean-Pierre Timmermans, Dirk Adriaensen
    Pages 1-5
  3. Inge Brouns, Isabel Pintelon, Jean-Pierre Timmermans, Dirk Adriaensen
    Pages 7-15
  4. Inge Brouns, Isabel Pintelon, Jean-Pierre Timmermans, Dirk Adriaensen
    Pages 17-18
  5. Inge Brouns, Isabel Pintelon, Jean-Pierre Timmermans, Dirk Adriaensen
    Pages 19-21
  6. Inge Brouns, Isabel Pintelon, Jean-Pierre Timmermans, Dirk Adriaensen
    Pages 23-77
  7. Inge Brouns, Isabel Pintelon, Jean-Pierre Timmermans, Dirk Adriaensen
    Pages 79-89
  8. Inge Brouns, Isabel Pintelon, Jean-Pierre Timmermans, Dirk Adriaensen
    Pages 91-94
  9. Back Matter
    Pages 95-118

About this book

Introduction

Airway sensory nerve terminals are tailored to detect changes in the physical and chemical environment, thereby supplying local pulmonary information to the central nervous system. Since most intrapulmonary nerve terminals arise from fibres travelling in the vagal nerve, the classification of ‘sensory airway receptors’ is largely based on their action potential characteristics, electrophysiologically registered from the vagal nerve.

However, the architecture of airways and lungs makes it nearly impossible to functionally locate the exact nerve terminals that are responsible for the transduction of a particular intrapulmonary stimulus.

In this monograph we focus on three sensory receptor end organs in lungs that are currently morphologically well-characterised: smooth muscle-associated airway receptors (SMARs), neuroepithelial bodies (NEBs) and visceral pleura receptors (VPRs). Unravelling the main functional morphological and neurochemical characteristics of these sensory receptors using advanced immunohistochemistry and confocal microscopy has already allowed us to draw important conclusions about their potential function(s).

The current development of ex vivo lung models for the selective identification of SMARs, NEBs and VPRs using vital staining will certainly facilitate direct physiological studies of these morphologically well-characterised airway receptors, since these models allow direct live studies of their functional properties.

Keywords

airway environment breathing pattern cardiorespiratory homeostasis pulmonary system sensory nerves vagal afferents vagal sensory neurons

Authors and affiliations

  1. 1., Department of Veterinary SciencesUniversity of AntwerpAntwerpBelgium
  2. 2., Department of Veterinary SciencesUniversity of AntwerpAntwerpBelgium
  3. 3.Lab. Cell Biology and Histology, Dept. Veterinary SciencesUniversity of AntwerpAntwerpenBelgium
  4. 4.Lab. Cell Biology and Histology, Dept. Veterinary SciencesUniversity of AntwerpAntwerpenBelgium

Bibliographic information

  • Book Title Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors
  • Authors Inge Brouns
    Isabel Pintelon
    Jean-Pierre Timmermans
    Dirk Adriaensen
  • Series Title Advances in Anatomy, Embryology and Cell Biology
  • DOI https://doi.org/10.1007/978-3-642-22772-1
  • Copyright Information Springer-Verlag Berlin Heidelberg 2012
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine Medicine (R0)
  • Softcover ISBN 978-3-642-22771-4
  • eBook ISBN 978-3-642-22772-1
  • Series ISSN 0301-5556
  • Edition Number 1
  • Number of Pages XII, 118
  • Number of Illustrations 2 b/w illustrations, 21 illustrations in colour
  • Topics Human Physiology
    Neurochemistry
  • Buy this book on publisher's site
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