© 2011


  • Allen W. Nicholson

Part of the Nucleic Acids and Molecular Biology book series (NUCLEIC)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Marc Ribó, Antoni Benito, Maria Vilanova
    Pages 55-88
  3. Pavel Ivanov, Paul Anderson
    Pages 115-134
  4. Gregor Meyers, Tillmann Rümenapf, John Ziebuhr
    Pages 135-165
  5. Jeong Ho Chang, Song Xiang, Liang Tong
    Pages 167-192
  6. Rute G. Matos, Vânia Pobre, Filipa P. Reis, Michal Malecki, José M. Andrade, Cecília M. Arraiano
    Pages 193-222
  7. Karl-Peter Hopfner, Sophia Hartung
    Pages 223-244
  8. Ciarán Condon, Laetitia Gilet
    Pages 245-267
  9. Thomas Hollis, Nadine M. Shaban
    Pages 299-317
  10. Andrey S. Krasilnikov
    Pages 319-342
  11. Back Matter
    Pages 399-403

About this book


Ribonucleases are a ubiquitous and functionally diverse group of enzymes that have a common ability to cleave RNA. Either through scission of internal phosphodiesters, or removal of nucleotides from RNA 5’ or 3’ ends, ribonucleases perform essential roles in gene expression and regulation, genome replication and maintenance, host defense, stress response, and viral strategies of infection. Ribonucleases have also served as highly informative models to understand virtually every aspect of biomolecular structure and function. The fifteen chapters in this volume are written by recognized researchers in the field, and provide in-depth analyses of the major ribonuclease families. Particular focus is given to the relation of ribonuclease structure and mechanism to biological function, as well as ribonuclease dysfunction in certain disease states. Other topics include the evolutionary genetics and functional diversification of ribonucleases, engineered ribonucleases as anti-cancer agents, the mechanisms of action of artificial ribonucleases, and ribonucleases as models to understand protein folding and stability. This volume should serve as an essential reference for a broad range of researchers and educators with interests in RNA metabolism, enzymology, and gene regulation.


RNA RNAse catalysis catalytic enzyme endonuclease enzyme exonuclease nuclease ribonuclease

Editors and affiliations

  • Allen W. Nicholson
    • 1
  1. 1.Temple UniversityPhiladelphia, PA 19122USA

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