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Pediatric Clinical Pharmacology

  • Hannsjörg W. Seyberth
  • Anders Rane
  • Matthias Schwab
Book

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 205)

Table of contents

  1. Front Matter
    Pages i-xii
    PDF

  2. General Considerations and Methodological Aspects

    1. Front Matter
      Pages 1-1
      PDF
    2. Basics and Dynamics of Neonatal and Pediatric Pharmacology
      Hannsjörg W. Seyberth, Ralph E. Kauffman
      Pages 3-49
    3. Developmental Pharmacokinetics
      Johannes N. van den Anker, Matthias Schwab, Gregory L. Kearns
      Pages 51-75
    4. Principles of Therapeutic Drug Monitoring
      Wei Zhao, Evelyne Jacqz-Aigrain
      Pages 77-90
    5. Drug Delivery and Formulations
      Jörg Breitkreutz, Joachim Boos
      Pages 91-107

  3. Development of Pediatric Medicines

    1. Front Matter
      Pages 109-109
      PDF
    2. Development of Paediatric Medicines: Concepts and Principles
      Klaus Rose, Oscar Della Pasqua
      Pages 111-124
    3. Study Design and Simulation Approach
      Stephanie Läer, Bernd Meibohm
      Pages 125-148
    4. Efficacy Assessment in Paediatric Studies
      Siri Wang, Pirjo Laitinen-Parkkonen
      Pages 149-168
    5. Safety Assessment in Pediatric Studies
      Gideon Koren, Abdelbasset Elzagallaai, Fatma Etwel
      Pages 169-180
    6. Small Sample Approach, and Statistical and Epidemiological Aspects
      Martin Offringa, Hanneke van der Lee
      Pages 181-202
    7. Sample Collection, Biobanking, and Analysis
      Maurice J. Ahsman, Dick Tibboel, Ron A. A. Mathot, Saskia N. de Wildt
      Pages 203-217
    8. Ethical Considerations in Conducting Pediatric Research
      Michelle Roth-Cline, Jason Gerson, Patricia Bright, Catherine S. Lee, Robert M. Nelson
      Pages 219-244
    9. Pediatric Regulatory Initiatives
      Steven Hirschfeld, Agnes Saint-Raymond
      Pages 245-268

  4. Specific Pediatric Pharmacology

    1. Front Matter
      Pages 269-269
      PDF
    2. Fetal Medicine and Treatment
      Magnus Westgren
      Pages 271-283
    3. Fetal Risks of Maternal Pharmacotherapy: Identifying Signals
      Gideon Koren
      Pages 285-294
    4. Antiepileptic Treatment in Pregnant Women: Morphological and Behavioural Effects
      Torbjörn Tomson, Dina Battino
      Pages 295-315
    5. Preventive Medicines
      Ulrich Heininger
      Pages 317-337
    6. Postmarketing Surveillance
      Vera Vlahović-Palčevski, Dirk Mentzer
      Pages 339-351
    7. Global Aspects of Drug Development
      Kalle Hoppu, Hans V. Hogerzeil
      Pages 353-372
  5. Back Matter
    Pages 373-383
    PDF

About this book

Introduction

The objective of this volume is to give an overview of the present state of the art of pediatric clinical pharmacology including developmental physiology, pediatric-specific pathology, special tools and methods for development of drugs for children (assessment of efficacy, toxicity, long-term safety etc.) as well as regulatory and ethical knowledge and skills. In the future, structural and educational changes have to lead back to a closer cooperation and interaction of pediatrics with (clinical) pharmacology and pharmacy.

Keywords

Drug Treatment in Children Pediatric Pharmacology

Editors and affiliations

  • Hannsjörg W. Seyberth
    • 1
  • Anders Rane
    • 2
  • Matthias Schwab
    • 3
  1. 1.Klinik für Kinder- und JugendmedizinUniv.Klinikum MarburgMarburgGermany
  2. 2.Karolinska Institutet, Dept. Laboratory MedicineKarolinska University HostpitalStockholmSweden
  3. 3.für Klinische Pharmakologie (IKP)Dr. Margarete Fischer-Bosch InstitutStuttgartGermany

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